Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study

Siok Fong Chin, Johari Ibahim, Suzana Makpol, Noor Aini Abdul Hamid, Azian Abdul Latiff, Zaiton Zakaria, Musalmah Mazlan, Yasmin Anum Mohd Yusof, Aminuddin Abdul Karim, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months. Methods. Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3rd and 6th months. Results: HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the > 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the > 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the > 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05). Conclusion: The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.

Original languageEnglish
Article number42
JournalNutrition and Metabolism
Volume8
DOIs
Publication statusPublished - 2011

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Tocotrienols
Lipids
Placebos
Vitamin E
Vitamins
HDL Cholesterol
Oxidation-Reduction
Capsules
Age Groups
Antioxidants
Cholesterol
Health
Enzymes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

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Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults : A randomized controlled study. / Chin, Siok Fong; Ibahim, Johari; Makpol, Suzana; Abdul Hamid, Noor Aini; Abdul Latiff, Azian; Zakaria, Zaiton; Mazlan, Musalmah; Mohd Yusof, Yasmin Anum; Abdul Karim, Aminuddin; Wan Ngah, Wan Zurinah.

In: Nutrition and Metabolism, Vol. 8, 42, 2011.

Research output: Contribution to journalArticle

Chin, Siok Fong ; Ibahim, Johari ; Makpol, Suzana ; Abdul Hamid, Noor Aini ; Abdul Latiff, Azian ; Zakaria, Zaiton ; Mazlan, Musalmah ; Mohd Yusof, Yasmin Anum ; Abdul Karim, Aminuddin ; Wan Ngah, Wan Zurinah. / Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults : A randomized controlled study. In: Nutrition and Metabolism. 2011 ; Vol. 8.
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abstract = "Background: Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months. Methods. Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3rd and 6th months. Results: HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the > 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the > 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the > 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05). Conclusion: The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.",
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T1 - Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults

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AU - Chin, Siok Fong

AU - Ibahim, Johari

AU - Makpol, Suzana

AU - Abdul Hamid, Noor Aini

AU - Abdul Latiff, Azian

AU - Zakaria, Zaiton

AU - Mazlan, Musalmah

AU - Mohd Yusof, Yasmin Anum

AU - Abdul Karim, Aminuddin

AU - Wan Ngah, Wan Zurinah

PY - 2011

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AB - Background: Vitamin E supplements containing tocotrienols are now being recommended for optimum health but its effects are scarcely known. The objective was to determine the effects of Tocotrienol Rich Fraction (TRF) supplementation on lipid profile and oxidative status in healthy older individuals at a dose of 160 mg/day for 6 months. Methods. Sixty-two subjects were recruited from two age groups: 35-49 years (n = 31) and above 50 years (n = 31), and randomly assigned to receive either TRF or placebo capsules for six months. Blood samples were obtained at 0, 3rd and 6th months. Results: HDL-cholesterol in the TRF-supplemented group was elevated after 6 months (p < 0.01). Protein carbonyl contents were markedly decreased (p < 0.001), whereas AGE levels were lowered in the > 50 year-old group (p < 0.05). Plasma levels of total vitamin E particularly tocopherols were significantly increased in the TRF-supplemented group after 3 months (p < 0.01). Plasma total tocotrienols were only increased in the > 50 year-old group after receiving 6 months of TRF supplementation. Changes in enzyme activities were only observed in the > 50 year-old group. SOD activity was decreased after 3 (p < 0.05) and 6 (p < 0.05) months of TRF supplementation whereas CAT activity was decreased after 3 (p < 0.01) and 6 (p < 0.05) months in the placebo group. GPx activity was increased at 6 months for both treatment and placebo groups (p < 0.05). Conclusion: The observed improvement of plasma cholesterol, AGE and antioxidant vitamin levels as well as the reduced protein damage may indicate a restoration of redox balance after TRF supplementation, particularly in individuals over 50 years of age.

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