Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats

Nursiati M ohamad Taridi, Nazirah Abd Rani, Azian Abd Latiff, Wan Z urinah Wan Ngah, Musalmah Mazlan

Research output: Contribution to journalArticle

Abstract

Little is known about the effect of vitamin E on brain function. Therefore, in this study we evaluated the effect of tocotrienol rich fraction (TRF) on behavioral impairment and oxidative stress in aged rats. Thirty-six male Wistar rats (young: 3-months-old; aged: 21-months-old) were treated with either the control (olive oil) or TRF (200 mg/kg) for 3 months. Behavioral studies were performed using the open field test and Morris water maze (MWM) task. Blood was taken for assessment of DNA damage, plasma malondialdehyde (MDA) and vitamin E, and erythrocyte antioxidant enzyme activity. Brains were also collected to measure vitamin E levels. Results showed that aged rats exhibited reduced exploratory activity, enhanced anxiety and decreased spatial learning and memory compared with young rats. DNA damage and plasma MDA were increased, and vitamin E levels in plasma and brain were reduced in aged rats. Aged rats supplemented with TRF showed a markedly reduced level of anxiety, improved spatial learning and memory, reduced amount and severity of DNA damage, a reduced level of MDA, and increased levels of antioxidant enzyme activity and plasma/brain vitamin E compared with age-matched controls. In conclusion, TRF supplementation reverses spatial learning and memory decline and decreases oxidative stress in aged rats.

Original languageEnglish
Pages (from-to)855-869
Number of pages15
JournalLipids
Volume49
Issue number9
Publication statusPublished - 1 Sep 2014
Externally publishedYes

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Tocotrienols
Rats
Vitamin E
Data storage equipment
Malondialdehyde
Brain
DNA Damage
Plasmas
Oxidative stress
Enzyme activity
Oxidative Stress
Anxiety
Antioxidants
DNA
Enzymes
Spatial Memory
Spatial Learning
Wistar Rats
Erythrocytes
Blood

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Taridi, N. M. O., Abd Rani, N., Abd Latiff, A., Ngah, W. Z. U. W., & Mazlan, M. (2014). Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats. Lipids, 49(9), 855-869.

Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats. / Taridi, Nursiati M ohamad; Abd Rani, Nazirah; Abd Latiff, Azian; Ngah, Wan Z urinah Wan; Mazlan, Musalmah.

In: Lipids, Vol. 49, No. 9, 01.09.2014, p. 855-869.

Research output: Contribution to journalArticle

Taridi, NMO, Abd Rani, N, Abd Latiff, A, Ngah, WZUW & Mazlan, M 2014, 'Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats', Lipids, vol. 49, no. 9, pp. 855-869.
Taridi NMO, Abd Rani N, Abd Latiff A, Ngah WZUW, Mazlan M. Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats. Lipids. 2014 Sep 1;49(9):855-869.
Taridi, Nursiati M ohamad ; Abd Rani, Nazirah ; Abd Latiff, Azian ; Ngah, Wan Z urinah Wan ; Mazlan, Musalmah. / Tocotrienol rich fraction reverses age-related deficits in spatial learning and memory in aged rats. In: Lipids. 2014 ; Vol. 49, No. 9. pp. 855-869.
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