Tocotrienol Rich Fraction Reverses Age-Related Deficits in Spatial Learning and Memory in Aged Rats

Nursiati Mohamad Taridi, Nazirah Abd Rani, Azian Abd Latiff, Wan Zurinah Wan Ngah, Musalmah Mazlan

    Research output: Contribution to journalArticle

    17 Citations (Scopus)

    Abstract

    Abstract Little is known about the effect of vitamin E on brain function. Therefore, in this study we evaluated the effect of tocotrienol rich fraction (TRF) on behavioral impairment and oxidative stress in aged rats. Thirty-six male Wistar rats (young: 3-months-old; aged: 21-months-old) were treated with either the control (olive oil) or TRF (200 mg/kg) for 3 months. Behavioral studies were performed using the open field test and Morris water maze (MWM) task. Blood was taken for assessment of DNA damage, plasma malondialdehyde (MDA) and vitamin E, and erythrocyte antioxidant enzyme activity. Brains were also collected to measure vitamin E levels. Results showed that aged rats exhibited reduced exploratory activity, enhanced anxiety and decreased spatial learning and memory compared with young rats. DNA damage and plasma MDA were increased, and vitamin E levels in plasma and brain were reduced in aged rats. Aged rats supplemented with TRF showed a markedly reduced level of anxiety, improved spatial learning and memory, reduced amount and severity of DNA damage, a reduced level of MDA, and increased levels of antioxidant enzyme activity and plasma/brain vitamin E compared with age-matched controls. In conclusion, TRF supplementation reverses spatial learning and memory decline and decreases oxidative stress in aged rats.

    Original languageEnglish
    JournalLipids
    DOIs
    Publication statusAccepted/In press - 12 Jul 2014

    Fingerprint

    Tocotrienols
    Rats
    Vitamin E
    Data storage equipment
    Malondialdehyde
    Brain
    DNA Damage
    Plasmas
    Oxidative stress
    Enzyme activity
    Oxidative Stress
    Anxiety
    Antioxidants
    DNA
    Enzymes
    Spatial Memory
    Spatial Learning
    Wistar Rats
    Erythrocytes
    Blood

    Keywords

    • Behavioural impairments
    • Brain aging
    • Memory
    • Morris water maze task
    • Open field test
    • Spatial learning
    • Tocotrienol rich fraction
    • Working memory

    ASJC Scopus subject areas

    • Organic Chemistry
    • Cell Biology
    • Biochemistry

    Cite this

    Taridi, N. M., Abd Rani, N., Abd Latiff, A., Wan Ngah, W. Z., & Mazlan, M. (Accepted/In press). Tocotrienol Rich Fraction Reverses Age-Related Deficits in Spatial Learning and Memory in Aged Rats. Lipids. https://doi.org/10.1007/s11745-014-3919-2

    Tocotrienol Rich Fraction Reverses Age-Related Deficits in Spatial Learning and Memory in Aged Rats. / Taridi, Nursiati Mohamad; Abd Rani, Nazirah; Abd Latiff, Azian; Wan Ngah, Wan Zurinah; Mazlan, Musalmah.

    In: Lipids, 12.07.2014.

    Research output: Contribution to journalArticle

    Taridi, Nursiati Mohamad ; Abd Rani, Nazirah ; Abd Latiff, Azian ; Wan Ngah, Wan Zurinah ; Mazlan, Musalmah. / Tocotrienol Rich Fraction Reverses Age-Related Deficits in Spatial Learning and Memory in Aged Rats. In: Lipids. 2014.
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