Tocotrienol and physiology of reproduction

M. H. Rajikin, Norfilza Mohd Mokhtar, A. Chatterjee, Y. S. Kamsani

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The majority of earlier studies on vitamin E have focused on its total forms without considering single isoform. Compared to tocopherols, tocotrienols have been poorly studied (Sen et al., 2006, 2007b; Miyamoto et al., 2009). The research trend has, however, been shifted to isoforms of vitamin E other than alpha-tocopherol, namely, the tocotrienols (TCT) (Rahmat et al., 1993). TCT is now found to possess neuroprotective, anticancer, antioxidant, and cholesterol-lowering properties that are different from tocopherol (TCP) isomers (Sen et al., 2004). Deficiency of Vitamin E also causes degenerative diseases such as gamma ataxia and Duchenne muscular dystrophy-like muscle degeneration (Aggarwal et al., 2010). It has been documented that many of the beneficial effects of a-tocotrienol are not shared by α-tocopherol (Sen et al., 2006). Since α-TCT shows better mobility through the cell membrane (Suzuki et al., 1993), tocotrienols are believed to have much more potent antioxidant properties than α-tocopherol (Serbinova et al., 1991). In cardiovascular diseases, efficacy of δ-and γ-TCT, the most potent isomers in supporting cardiac health such as coronary heart disease, ischemia-induced arrhythmia, and reduced heart rate accompanied by improved myocardial efficiency are well evident (Rasool et al., 2008). In addition, the beneficial effect of TCT in preventing osteoporosis by increasing bone formation and suppressing bone resorption has been documented (Maniam et al., 2008).

Original languageEnglish
Title of host publicationTocotrienols
Subtitle of host publicationVitamin E beyond Tocopherols, Second Edition
PublisherCRC Press
Pages323-332
Number of pages10
ISBN (Electronic)9781439884430
ISBN (Print)9781439884416
DOIs
Publication statusPublished - 1 Jan 2012

Fingerprint

Tocotrienols
tocotrienols
Vitamins
Physiology
Reproduction
physiology
Antioxidants
Isomers
Tocopherols
Bone
tocopherols
Cholesterol
Vitamin E
Cell membranes
Muscle
Health
isomers
vitamin E
Protein Isoforms
Vitamin E Deficiency

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Engineering(all)
  • Agricultural and Biological Sciences(all)

Cite this

Rajikin, M. H., Mohd Mokhtar, N., Chatterjee, A., & Kamsani, Y. S. (2012). Tocotrienol and physiology of reproduction. In Tocotrienols: Vitamin E beyond Tocopherols, Second Edition (pp. 323-332). CRC Press. https://doi.org/10.1201/b12502

Tocotrienol and physiology of reproduction. / Rajikin, M. H.; Mohd Mokhtar, Norfilza; Chatterjee, A.; Kamsani, Y. S.

Tocotrienols: Vitamin E beyond Tocopherols, Second Edition. CRC Press, 2012. p. 323-332.

Research output: Chapter in Book/Report/Conference proceedingChapter

Rajikin, MH, Mohd Mokhtar, N, Chatterjee, A & Kamsani, YS 2012, Tocotrienol and physiology of reproduction. in Tocotrienols: Vitamin E beyond Tocopherols, Second Edition. CRC Press, pp. 323-332. https://doi.org/10.1201/b12502
Rajikin MH, Mohd Mokhtar N, Chatterjee A, Kamsani YS. Tocotrienol and physiology of reproduction. In Tocotrienols: Vitamin E beyond Tocopherols, Second Edition. CRC Press. 2012. p. 323-332 https://doi.org/10.1201/b12502
Rajikin, M. H. ; Mohd Mokhtar, Norfilza ; Chatterjee, A. ; Kamsani, Y. S. / Tocotrienol and physiology of reproduction. Tocotrienols: Vitamin E beyond Tocopherols, Second Edition. CRC Press, 2012. pp. 323-332
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