Tocotrienol and its role in chronic diseases

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Abstract

Tocotrienol is a member of vitamin E family and is well-known for its antioxidant and anti-inflammatory properties. It is also a suppressor of mevalonate pathway responsible for cholesterol and prenylated protein synthesis. This review aimed to discuss the health beneficial effects of tocotrienol, specifically in preventing or treating hyperlipidaemia, diabetes mellitus, osteoporosis and cancer with respect to these properties. Evidence from in vitro, in vivo and human studies has been examined. It is revealed that tocotrienol shows promising effects in preventing or treating the health conditions previously mentioned in in vivo and in vitro models. In some cases, alpha-tocopherol attenuates the biological activity of tocotrienol. Except for its cholesterol-lowering effects, data on the health-promoting effects of tocotrienol in human are limited. As a conclusion, the encouraging results on the health beneficial effects of tocotrienol should motivate researchers to explore its potential use in human.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages97-130
Number of pages34
Volume928
DOIs
Publication statusPublished - 1 Sep 2016

Publication series

NameAdvances in Experimental Medicine and Biology
Volume928
ISSN (Print)00652598
ISSN (Electronic)22148019

Fingerprint

Tocotrienols
Chronic Disease
Health
Cholesterol
Mevalonic Acid
alpha-Tocopherol
Medical problems
Bioactivity
Hyperlipidemias
Vitamin E
Osteoporosis
Diabetes Mellitus
Anti-Inflammatory Agents
Antioxidants
Research Personnel

Keywords

  • Bone
  • Cancer
  • Cholesterol
  • Diabetes
  • Glucose
  • Osteoporosis
  • Tocopherol
  • Tocotrienol
  • Vitamin E

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kok Yong, C., Pang, K. L., & Soelaiman, I. N. (2016). Tocotrienol and its role in chronic diseases. In Advances in Experimental Medicine and Biology (Vol. 928, pp. 97-130). (Advances in Experimental Medicine and Biology; Vol. 928). Springer New York LLC. https://doi.org/10.1007/978-3-319-41334-1_5

Tocotrienol and its role in chronic diseases. / Kok Yong, Chin; Pang, Kok Lun; Soelaiman, Ima Nirwana.

Advances in Experimental Medicine and Biology. Vol. 928 Springer New York LLC, 2016. p. 97-130 (Advances in Experimental Medicine and Biology; Vol. 928).

Research output: Chapter in Book/Report/Conference proceedingChapter

Kok Yong, C, Pang, KL & Soelaiman, IN 2016, Tocotrienol and its role in chronic diseases. in Advances in Experimental Medicine and Biology. vol. 928, Advances in Experimental Medicine and Biology, vol. 928, Springer New York LLC, pp. 97-130. https://doi.org/10.1007/978-3-319-41334-1_5
Kok Yong C, Pang KL, Soelaiman IN. Tocotrienol and its role in chronic diseases. In Advances in Experimental Medicine and Biology. Vol. 928. Springer New York LLC. 2016. p. 97-130. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-41334-1_5
Kok Yong, Chin ; Pang, Kok Lun ; Soelaiman, Ima Nirwana. / Tocotrienol and its role in chronic diseases. Advances in Experimental Medicine and Biology. Vol. 928 Springer New York LLC, 2016. pp. 97-130 (Advances in Experimental Medicine and Biology).
@inbook{981fd13a26fd4da8b8ef112006d6a427,
title = "Tocotrienol and its role in chronic diseases",
abstract = "Tocotrienol is a member of vitamin E family and is well-known for its antioxidant and anti-inflammatory properties. It is also a suppressor of mevalonate pathway responsible for cholesterol and prenylated protein synthesis. This review aimed to discuss the health beneficial effects of tocotrienol, specifically in preventing or treating hyperlipidaemia, diabetes mellitus, osteoporosis and cancer with respect to these properties. Evidence from in vitro, in vivo and human studies has been examined. It is revealed that tocotrienol shows promising effects in preventing or treating the health conditions previously mentioned in in vivo and in vitro models. In some cases, alpha-tocopherol attenuates the biological activity of tocotrienol. Except for its cholesterol-lowering effects, data on the health-promoting effects of tocotrienol in human are limited. As a conclusion, the encouraging results on the health beneficial effects of tocotrienol should motivate researchers to explore its potential use in human.",
keywords = "Bone, Cancer, Cholesterol, Diabetes, Glucose, Osteoporosis, Tocopherol, Tocotrienol, Vitamin E",
author = "{Kok Yong}, Chin and Pang, {Kok Lun} and Soelaiman, {Ima Nirwana}",
year = "2016",
month = "9",
day = "1",
doi = "10.1007/978-3-319-41334-1_5",
language = "English",
volume = "928",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "97--130",
booktitle = "Advances in Experimental Medicine and Biology",

}

TY - CHAP

T1 - Tocotrienol and its role in chronic diseases

AU - Kok Yong, Chin

AU - Pang, Kok Lun

AU - Soelaiman, Ima Nirwana

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Tocotrienol is a member of vitamin E family and is well-known for its antioxidant and anti-inflammatory properties. It is also a suppressor of mevalonate pathway responsible for cholesterol and prenylated protein synthesis. This review aimed to discuss the health beneficial effects of tocotrienol, specifically in preventing or treating hyperlipidaemia, diabetes mellitus, osteoporosis and cancer with respect to these properties. Evidence from in vitro, in vivo and human studies has been examined. It is revealed that tocotrienol shows promising effects in preventing or treating the health conditions previously mentioned in in vivo and in vitro models. In some cases, alpha-tocopherol attenuates the biological activity of tocotrienol. Except for its cholesterol-lowering effects, data on the health-promoting effects of tocotrienol in human are limited. As a conclusion, the encouraging results on the health beneficial effects of tocotrienol should motivate researchers to explore its potential use in human.

AB - Tocotrienol is a member of vitamin E family and is well-known for its antioxidant and anti-inflammatory properties. It is also a suppressor of mevalonate pathway responsible for cholesterol and prenylated protein synthesis. This review aimed to discuss the health beneficial effects of tocotrienol, specifically in preventing or treating hyperlipidaemia, diabetes mellitus, osteoporosis and cancer with respect to these properties. Evidence from in vitro, in vivo and human studies has been examined. It is revealed that tocotrienol shows promising effects in preventing or treating the health conditions previously mentioned in in vivo and in vitro models. In some cases, alpha-tocopherol attenuates the biological activity of tocotrienol. Except for its cholesterol-lowering effects, data on the health-promoting effects of tocotrienol in human are limited. As a conclusion, the encouraging results on the health beneficial effects of tocotrienol should motivate researchers to explore its potential use in human.

KW - Bone

KW - Cancer

KW - Cholesterol

KW - Diabetes

KW - Glucose

KW - Osteoporosis

KW - Tocopherol

KW - Tocotrienol

KW - Vitamin E

UR - http://www.scopus.com/inward/record.url?scp=84988971731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84988971731&partnerID=8YFLogxK

U2 - 10.1007/978-3-319-41334-1_5

DO - 10.1007/978-3-319-41334-1_5

M3 - Chapter

C2 - 27671814

AN - SCOPUS:84988971731

VL - 928

T3 - Advances in Experimental Medicine and Biology

SP - 97

EP - 130

BT - Advances in Experimental Medicine and Biology

PB - Springer New York LLC

ER -