Tocopherol and tocotrienol: Therapeutic potential in animal models of stress

Research output: Contribution to journalReview article

Abstract

Background: Scientific reports had shown that stress is related to numerous pathological changes in the body. These pathological changes can bring about numerous diseases and can significantly cause negative effects in an individual. These include gastric ulcer, liver pathology and neurobehavioral changes. A common pathogenesis in many diseases related to stress involves oxidative damage. Therefore, the administration of antioxidants such as vitamin E is a reasonable therapeutic approach. However, there is conflicting evidence about antioxidant supplementation. Objective: The aim of this work was to summarize documented reports on the effects of tocopherol and tocotrienol on various pathological changes induced by stress. Results and Conclusion: This review will reveal the scientific evidence of enteral supplementation of vitamin E in the forms of tocotrienol and tocopherol in animal models of stress. These models mimic the stress endured by critically ill patients in a clinical setting and psychological stress in individuals. Positive outcomes from enteral feeding of vitamin E in reducing the occurrence of stress-induced pathological changes are discussed in this review. These positive findings include their ability to reduced stress-induced gastric ulcers, elevated liver enzymes and improved locomotors activity. Evidences showing tocotrienol and tocopherol effects are not just related to its ability to reduce oxidative stress but also acting on other mechanism, are discussed.

Original languageEnglish
Pages (from-to)1456-1462
Number of pages7
JournalCurrent Drug Targets
Volume19
Issue number12
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Tocotrienols
Tocopherols
Vitamin E
Animals
Aptitude
Animal Models
Stomach Ulcer
Oxidative Stress
Antioxidants
Oxidative stress
Liver
Enteral Nutrition
Locomotion
Psychological Stress
Critical Illness
Small Intestine
Therapeutics
Pathology
Enzymes

Keywords

  • Gastric ulcer
  • Hormones
  • Lipid peroxidation
  • Major organs
  • Stress
  • Tocopherol
  • Tocotrienol

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Tocopherol and tocotrienol : Therapeutic potential in animal models of stress. / Mohd Fahami, Nur Azlina; Mohd Saad, Qodriyah; Yusof, Kamisah.

In: Current Drug Targets, Vol. 19, No. 12, 01.01.2018, p. 1456-1462.

Research output: Contribution to journalReview article

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