Tinospora species

An overview of their modulating effects on the immune system

Md Areeful Haque, Ibrahim Jantan, Bukhari Syed Nasir Abbas

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Ethnopharmacological relevance Studies on the effects of natural immunomodulators to heal various diseases related to the immune system have been a growing interest in recent years. Amongst the medicinal plants, Tinospora species (family; Menispermaceae) have been one of the widely investigated plants for their modulating effects on the immune system due to their wide use in ethnomedicine to treat various ailments related to immune-related diseases. However, their ethnopharmacological uses are mainly with limited or without scientific basis. Aim of this review In this article, we have reviewed the literature on the phytochemicals of several Tinospora species, which have shown strong immunomodulatory effects and critically analyzed the reports to provide perspectives and instructions for future research for the plants as a potential source of new immunomodulators for use as medicinal agents or dietary supplements. Materials and methods Electronic search on worldwide accepted scientific databases (Google Scholar, Science Direct, SciFinder, Web of Science, PubMed, Wiley Online Library, ACS Publications Today) was performed to compile the relevant information. Some information was obtained from books, database on medicinal plants used in Ayurveda, MSc dissertations and herbal classics books written in various languages. Results T. cordifolia, T. crispa, T. sinensis, T. smilacina, T. bakis, and T. sagittata have been reported to possess significant immunomodulatory effects. For a few decades, initiatives in molecular research on the effects of these species on the immune system have been carried out. However, most of the biological and pharmacological studies were carried out using the crude extracts of plants. The bioactive compounds contributing to the bioactivities have not been properly identified, and mechanistic studies to understand the immunomodulatory effects of the plants are limited by many considerations with regard to design, conduct, and interpretation. Conclusion The plant extracts and their active constituents should be subjected to more detail mechanistic studies, in vivo investigations in various animal models including pharmacokinetic and bioavailability studies, and elaborate toxicity study before submission to clinical trials.

Original languageEnglish
Pages (from-to)67-85
Number of pages19
JournalJournal of Ethnopharmacology
Volume207
DOIs
Publication statusPublished - 31 Jul 2017

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Tinospora
Immune System
Immunologic Factors
Medicinal Plants
Maianthemum
Menispermaceae
Databases
Immune System Diseases
Plant Extracts
Phytochemicals
Traditional Medicine
Dietary Supplements
Complex Mixtures
PubMed
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Animal Models
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Keywords

  • Dietary supplements
  • Immune system
  • Immunomodulating effects
  • Phytochemicals
  • Tinospora species

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Cite this

Tinospora species : An overview of their modulating effects on the immune system. / Haque, Md Areeful; Jantan, Ibrahim; Syed Nasir Abbas, Bukhari.

In: Journal of Ethnopharmacology, Vol. 207, 31.07.2017, p. 67-85.

Research output: Contribution to journalReview article

Haque, Md Areeful ; Jantan, Ibrahim ; Syed Nasir Abbas, Bukhari. / Tinospora species : An overview of their modulating effects on the immune system. In: Journal of Ethnopharmacology. 2017 ; Vol. 207. pp. 67-85.
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abstract = "Ethnopharmacological relevance Studies on the effects of natural immunomodulators to heal various diseases related to the immune system have been a growing interest in recent years. Amongst the medicinal plants, Tinospora species (family; Menispermaceae) have been one of the widely investigated plants for their modulating effects on the immune system due to their wide use in ethnomedicine to treat various ailments related to immune-related diseases. However, their ethnopharmacological uses are mainly with limited or without scientific basis. Aim of this review In this article, we have reviewed the literature on the phytochemicals of several Tinospora species, which have shown strong immunomodulatory effects and critically analyzed the reports to provide perspectives and instructions for future research for the plants as a potential source of new immunomodulators for use as medicinal agents or dietary supplements. Materials and methods Electronic search on worldwide accepted scientific databases (Google Scholar, Science Direct, SciFinder, Web of Science, PubMed, Wiley Online Library, ACS Publications Today) was performed to compile the relevant information. Some information was obtained from books, database on medicinal plants used in Ayurveda, MSc dissertations and herbal classics books written in various languages. Results T. cordifolia, T. crispa, T. sinensis, T. smilacina, T. bakis, and T. sagittata have been reported to possess significant immunomodulatory effects. For a few decades, initiatives in molecular research on the effects of these species on the immune system have been carried out. However, most of the biological and pharmacological studies were carried out using the crude extracts of plants. The bioactive compounds contributing to the bioactivities have not been properly identified, and mechanistic studies to understand the immunomodulatory effects of the plants are limited by many considerations with regard to design, conduct, and interpretation. Conclusion The plant extracts and their active constituents should be subjected to more detail mechanistic studies, in vivo investigations in various animal models including pharmacokinetic and bioavailability studies, and elaborate toxicity study before submission to clinical trials.",
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