Tinospora crispa (L.) Hook. f. & Thomson: A review of its ethnobotanical, phytochemical, and pharmacological aspects

Waqas Ahmad, Ibrahim Jantan, Bukhari Syed Nasir Abbas

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Tinospora crispa (L.) Hook. f. & Thomson (Menispermaceae), found in the rainforests or mixed deciduous forests in Asia and Africa, is used in traditional medicines to treat numerous health conditions. This review summarizes the up-to-date reports about the ethnobotany, phytochemistry, pharmacological activities, toxicology, and clinical trials of the plant. It also provides critical assessment about the present knowledge of the plant which could contribute toward improving its prospect as a source of lead molecules for drug discovery. The plant has been used traditionally in the treatment of jaundice, rheumatism, urinary disorders, fever, malaria, diabetes, internal inflammation, fracture, scabies, hypertension, reducing thirst, increasing appetite, cooling down the body temperature, and maintaining good health. Phytochemical analyses of T. crispa revealed the presence of alkaloids, flavonoids, and flavone glycosides, triterpenes, diterpenes and diterpene glycosides, cis clerodane-type furanoditerpenoids, lactones, sterols, lignans, and nucleosides. Studies showed that the crude extracts and isolated compounds of T. crispa possessed a broad range of pharmacological activities such as anti-inflammatory, antioxidant, immunomodulatory, cytotoxic, antimalarial, cardioprotective, and anti-diabetic activities. Most pharmacological studies were based on crude extracts of the plant and the bioactive compounds responsible for the bioactivities have not been well identified. Further investigations are required to transform the experience-based claims on the use of T. crispa in traditional medicine practices into evidence-based information. The plant extract used in pharmacological and biological studies should be qualitatively and quantitatively analyzed based on its biomarkers. There should be detail in vitro and in vivo studies on the mechanisms of action of the pure bioactive compounds and more elaborate toxicity study to ensure safety of the plant for human use. More clinical trials are encouraged to be carried out if there are sufficient preclinical and safety data.

Original languageEnglish
Article number59
JournalFrontiers in Pharmacology
Volume7
Issue numberMAR
DOIs
Publication statusPublished - 21 Mar 2016

Fingerprint

Tinospora
Phytochemicals
Pharmacology
flavone
Diterpenes
Traditional Medicine
Glycosides
Complex Mixtures
Menispermaceae
Ethnobotany
Clerodane Diterpenes
Clinical Trials
Safety
Thirst
Scabies
Lignans
Triterpenes
Evidence-Based Practice
Plant Extracts
Health

Keywords

  • Clinical trials
  • Pharmacological activities
  • Phytochemistry
  • Tinospora crispa
  • Toxicity studies
  • Traditional uses

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

Cite this

Tinospora crispa (L.) Hook. f. & Thomson : A review of its ethnobotanical, phytochemical, and pharmacological aspects. / Ahmad, Waqas; Jantan, Ibrahim; Syed Nasir Abbas, Bukhari.

In: Frontiers in Pharmacology, Vol. 7, No. MAR, 59, 21.03.2016.

Research output: Contribution to journalReview article

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