Thyroid-stimulating hormone is significantly associated with bone health status in men

Chin Kok Yong, Ima Nirwana Soelaiman, Isa Naina Mohamed, Amilia Aminuddin, Mohamad Hanapi Johari, Wan Zurinah Wan Ngah

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and Aim: Recent studies revealed a novel association between thyroid-stimulating hormone (TSH) and bone health status in healthy male populations. The present study aimed to validate this association and provide new information on the relationship between TSH levels and calcaneal speed of sound (SOS) in men. Methods: This cross-sectional study recruited 681 men with complete data of calcaneal SOS, body anthropometry, serum TSH, free triiodothyronine (FT3) and free thyroxine (FT4) levels. Results: All subjects had FT3 and FT4 levels within the in-house reference range and 13 subjects had lower than normal TSH levels. The results revealed that the SOS value of subjects was significantly associated with TSH after multiple adjustments (p<0.05). When subjects were divided into quintiles according to their TSH levels, the difference of SOS between men with low-normal TSH and high-normal TSH contributed significantly to the association between TSH and bone health status (p<0.05). The significance of the association persisted with the inclusion and exclusion of subclinical hyperthyroid subjects. Conclusions: There was a significant association between TSH levels and bone health status in men as assessed by quantitative ultrasound. This age-independent association between TSH and SOS might explain some of the individual variation of bone health status in men.

Original languageEnglish
Pages (from-to)857-863
Number of pages7
JournalInternational Journal of Medical Sciences
Volume10
Issue number7
DOIs
Publication statusPublished - 2013

Fingerprint

Thyrotropin
Health Status
Bone and Bones
Anthropometry
Triiodothyronine
Hyperthyroidism
Thyroxine
Reference Values
Cross-Sectional Studies

Keywords

  • Bone
  • Calcaneus
  • Men
  • Thyroid-stimulating hormone

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thyroid-stimulating hormone is significantly associated with bone health status in men. / Kok Yong, Chin; Soelaiman, Ima Nirwana; Naina Mohamed, Isa; Aminuddin, Amilia; Johari, Mohamad Hanapi; Wan Ngah, Wan Zurinah.

In: International Journal of Medical Sciences, Vol. 10, No. 7, 2013, p. 857-863.

Research output: Contribution to journalArticle

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AU - Johari, Mohamad Hanapi

AU - Wan Ngah, Wan Zurinah

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