Thyroid carcinoma in patients with familial adenomatous polyposis

Rohaizak Muhammad, Ali Yaakub Jasmi, Mohd Ali Mohd Ismail, Mohd Johan Julia Munchar, Freda Andrea Meah

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

There has been a growing awareness of the association between papillary thyroid carcinoma and familial adenomatous polyposis (FAP). The cases of four young patients with papiliary thyroid carcinoma occurring with FAP are presented. Three patients underwent surgery to provide specimens for detailed histological examination. The surgical specimens showed well-encapsulated multicentric tumours exhibiting a predominantly papillary architectural growth pattern. In some areas, follicular architecture and cribriform patterns were note. Atypical areas of spindle cells in a trabecular or solid configuration, which are not normally seen in classical papillary thyroid carcinoma, were evident. Malignant cells exhibited a graduation of cuboidal to tall cells with abundant amphophilic cytoplasm. The nuclei did not exhibit the typical nuclear clearing as seen in papillary thyroid carcinoma, but nuclear grooving and inclusions were noted. Psammoma bodies were not seen in any of the specimens. In a limited review of these patients, features such as young age at presentation multicentricity and unusual histology suggest that thyroid carcinoma associated with FAP may represent a distinct form of thyroid cancer.

Original languageEnglish
Pages (from-to)183-185
Number of pages3
JournalAsian Journal of Surgery
Volume26
Issue number3
Publication statusPublished - Jul 2003

Fingerprint

Adenomatous Polyposis Coli
Thyroid Neoplasms
Intranuclear Inclusion Bodies
Histology
Cytoplasm
Growth
Papillary Thyroid cancer
Neoplasms

ASJC Scopus subject areas

  • Surgery

Cite this

Muhammad, R., Jasmi, A. Y., Ismail, M. A. M., Munchar, M. J. J., & Meah, F. A. (2003). Thyroid carcinoma in patients with familial adenomatous polyposis. Asian Journal of Surgery, 26(3), 183-185.

Thyroid carcinoma in patients with familial adenomatous polyposis. / Muhammad, Rohaizak; Jasmi, Ali Yaakub; Ismail, Mohd Ali Mohd; Munchar, Mohd Johan Julia; Meah, Freda Andrea.

In: Asian Journal of Surgery, Vol. 26, No. 3, 07.2003, p. 183-185.

Research output: Contribution to journalArticle

Muhammad, R, Jasmi, AY, Ismail, MAM, Munchar, MJJ & Meah, FA 2003, 'Thyroid carcinoma in patients with familial adenomatous polyposis', Asian Journal of Surgery, vol. 26, no. 3, pp. 183-185.
Muhammad R, Jasmi AY, Ismail MAM, Munchar MJJ, Meah FA. Thyroid carcinoma in patients with familial adenomatous polyposis. Asian Journal of Surgery. 2003 Jul;26(3):183-185.
Muhammad, Rohaizak ; Jasmi, Ali Yaakub ; Ismail, Mohd Ali Mohd ; Munchar, Mohd Johan Julia ; Meah, Freda Andrea. / Thyroid carcinoma in patients with familial adenomatous polyposis. In: Asian Journal of Surgery. 2003 ; Vol. 26, No. 3. pp. 183-185.
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