Thyroid autoantibodies and associated complications during pregnancy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

This study was undertaken to determine the presence of thyroid autoantibodies and associated pregnancy complications from 49 pregnant women with thyroid disease. There were 31 (63) women with Graves' disease (GD) and 18 (37) with primary hypothyroidism (PHT). A total of 26 (53.1) women, 19 (61) with GD and seven (39) with PHT, had positive antibodies. Six had thyroid peroxidase antibodies (TPO), one with thyroglobulin antibody (TG) and eight had TSH receptor antibodies (TR). Two had a mixture of antibodies involving TG/TPO (one GD vs one PHT), four with TG/TPO/TR (all had GD) and five with TPO/TR (four with GD vs one with PHT). There were associations in women with positive thyroid antibodies and pre-eclampsia (15.4%), abruptio placenta (4), caesarean deliveries (31), postpartum thyroiditis (19.2%) and abnormal neonatal thyroid function (15.4%). Women with positive thyroid antibodies in pregnancy need close care during and after pregnancy, as they can develop complications affecting both mother and fetus.

Original languageEnglish
Pages (from-to)675-678
Number of pages4
JournalJournal of Obstetrics and Gynaecology
Volume30
Issue number7
DOIs
Publication statusPublished - Oct 2010

Fingerprint

Pregnancy Complications
Autoantibodies
Thyroid Gland
Antibodies
Graves Disease
Iodide Peroxidase
Hypothyroidism
Thyroglobulin
Postpartum Thyroiditis
Abruptio Placentae
Pregnancy
Thyroid Diseases
Pre-Eclampsia
Pregnant Women
Fetus
Mothers

Keywords

  • Hyperthyroidism
  • Hypothyroidism
  • Pregnancy
  • Thyroid antibodies

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Thyroid autoantibodies and associated complications during pregnancy. / Mohamed Ismail, Nor Azlin; Bakin, Y. D.; Mustafa, Norlaila; A. Wahab @ A. Rahman, Norasyikin; Johari, M. J M; Kamaruddin, Nor Azmi; Jamil, M. A.

In: Journal of Obstetrics and Gynaecology, Vol. 30, No. 7, 10.2010, p. 675-678.

Research output: Contribution to journalArticle

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