Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release

Haliza Katas, Chai Yi Wen, Muhammad Irfan Siddique, Zahid Hussain, Fatin Hanini Mohd Fadhil

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17-320 ± 20 nm, depending on CS concentration. The gels had Tgel of 23-28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h. Conclusion: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed.

Original languageEnglish
Pages (from-to)137-150
Number of pages14
JournalTherapeutic Delivery
Volume8
Issue number3
DOIs
Publication statusPublished - 1 Mar 2017

Fingerprint

Curcumin
Chitosan
Nanoparticles
Gels
Wounds and Injuries
Poloxamer
Rheology
Therapeutics
Drug Delivery Systems
Particle Size
Pharmaceutical Preparations
Wound Healing
Prostaglandins
Temperature
Drug Liberation
Genes

Keywords

  • Nanotechnology
  • RNA interfering
  • topical delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds : Synthesis and drug release. / Katas, Haliza; Wen, Chai Yi; Siddique, Muhammad Irfan; Hussain, Zahid; Mohd Fadhil, Fatin Hanini.

In: Therapeutic Delivery, Vol. 8, No. 3, 01.03.2017, p. 137-150.

Research output: Contribution to journalArticle

Katas, Haliza ; Wen, Chai Yi ; Siddique, Muhammad Irfan ; Hussain, Zahid ; Mohd Fadhil, Fatin Hanini. / Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds : Synthesis and drug release. In: Therapeutic Delivery. 2017 ; Vol. 8, No. 3. pp. 137-150.
@article{ed9466beff1f4c4a9a152b0da6763af4,
title = "Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds: Synthesis and drug release",
abstract = "Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25{\%} w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17-320 ± 20 nm, depending on CS concentration. The gels had Tgel of 23-28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h. Conclusion: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed.",
keywords = "Nanotechnology, RNA interfering, topical delivery",
author = "Haliza Katas and Wen, {Chai Yi} and Siddique, {Muhammad Irfan} and Zahid Hussain and {Mohd Fadhil}, {Fatin Hanini}",
year = "2017",
month = "3",
day = "1",
doi = "10.4155/tde-2016-0075",
language = "English",
volume = "8",
pages = "137--150",
journal = "Therapeutic Delivery",
issn = "2041-5990",
publisher = "Future Science",
number = "3",

}

TY - JOUR

T1 - Thermoresponsive curcumin/DsiRNA nanoparticle gels for the treatment of diabetic wounds

T2 - Synthesis and drug release

AU - Katas, Haliza

AU - Wen, Chai Yi

AU - Siddique, Muhammad Irfan

AU - Hussain, Zahid

AU - Mohd Fadhil, Fatin Hanini

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17-320 ± 20 nm, depending on CS concentration. The gels had Tgel of 23-28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h. Conclusion: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed.

AB - Aim: Chitosan (CS) has been extensively studied as drug delivery systems for wound healing. Results/methodology: CS nanoparticles were loaded with curcumin (Cur) and DsiRNA against prostaglandin transporter gene and they were incorporated into 20 and 25% w/v Pluronic F-127. The gels were later analyzed for their rheology, gelation temperature (Tgel), morphology, drug incorporation and in vitro drug release. The particle size was in the range of 231 ± 17-320 ± 20 nm, depending on CS concentration. The gels had Tgel of 23-28°C and exhibited sustained drug release with high accumulated amount of drugs over 48 h. Conclusion: A thermo-sensitive gel containing Cur/DsiRNA CS nanoparticles was successfully developed and has a great potential to be further developed.

KW - Nanotechnology

KW - RNA interfering

KW - topical delivery

UR - http://www.scopus.com/inward/record.url?scp=85011340333&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011340333&partnerID=8YFLogxK

U2 - 10.4155/tde-2016-0075

DO - 10.4155/tde-2016-0075

M3 - Article

C2 - 28145827

AN - SCOPUS:85011340333

VL - 8

SP - 137

EP - 150

JO - Therapeutic Delivery

JF - Therapeutic Delivery

SN - 2041-5990

IS - 3

ER -