Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases

Hassan Tidi Maharani, Paul J. McKiernan, Noel G. McElvaney, Sally Ann Cryan, Catherine M. Greene

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

miRNAs are short, nonprotein coding RNAs that regulate target gene expression principally by causing translational repression and/or mRNA degradation. miRNAs are involved in most mammalian biological processes and have pivotal roles in controlling the expression of factors involved in basal and stimulus-induced signaling pathways. Considering their central role in the regulation of gene expression, miRNAs represent therapeutic drug targets. Here we describe how miRNAs are involved in the regulation of aspects of innate immunity and inflammation, what happens when this goes awry, such as in the chronic inflammatory lung diseases cystic fibrosis and asthma, and discuss the current state-of-the-art miRNA-targeted therapeutics.

Original languageEnglish
Pages (from-to)359-368
Number of pages10
JournalExpert Review of Anti-Infective Therapy
Volume10
Issue number3
DOIs
Publication statusPublished - Mar 2012
Externally publishedYes

Fingerprint

MicroRNAs
Lung Diseases
Biological Phenomena
Therapeutics
RNA Stability
Gene Expression Regulation
Innate Immunity
Cystic Fibrosis
Asthma
RNA
Inflammation
Gene Expression
Pharmaceutical Preparations

Keywords

  • anti-miRs
  • asthma
  • cystic fibrosis
  • innate immunity
  • miR inhibitors
  • miRNA
  • miRNA therapeutics
  • Toll-like receptors

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology
  • Virology

Cite this

Tidi Maharani, H., McKiernan, P. J., McElvaney, N. G., Cryan, S. A., & Greene, C. M. (2012). Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. Expert Review of Anti-Infective Therapy, 10(3), 359-368. https://doi.org/10.1586/eri.11.175

Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. / Tidi Maharani, Hassan; McKiernan, Paul J.; McElvaney, Noel G.; Cryan, Sally Ann; Greene, Catherine M.

In: Expert Review of Anti-Infective Therapy, Vol. 10, No. 3, 03.2012, p. 359-368.

Research output: Contribution to journalReview article

Tidi Maharani, H, McKiernan, PJ, McElvaney, NG, Cryan, SA & Greene, CM 2012, 'Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases', Expert Review of Anti-Infective Therapy, vol. 10, no. 3, pp. 359-368. https://doi.org/10.1586/eri.11.175
Tidi Maharani, Hassan ; McKiernan, Paul J. ; McElvaney, Noel G. ; Cryan, Sally Ann ; Greene, Catherine M. / Therapeutic modulation of miRNA for the treatment of proinflammatory lung diseases. In: Expert Review of Anti-Infective Therapy. 2012 ; Vol. 10, No. 3. pp. 359-368.
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