Therapeutic effects of olive and its derivatives on osteoarthritis: From bench to bedside

Chin Kok Yong, Kok Lun Pang

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Osteoarthritis is a major cause of morbidity among the elderly worldwide. It is a disease characterized by localized inflammation of the joint and destruction of cartilage, leading to loss of function. Impaired chondrocyte repair mechanisms, due to inflammation, oxidative stress and autophagy, play important roles in the pathogenesis of osteoarthritis. Olive and its derivatives, which possess anti-inflammatory, antioxidant and autophagy-enhancing activities, are suitable candidates for therapeutic interventions for osteoarthritis. This review aimed to summarize the current evidence on the effects of olive and its derivatives, on osteoarthritis and chondrocytes. The literature on animal and human studies has demonstrated a beneficial effect of olive and its derivatives on the progression of osteoarthritis. In vitro studies have suggested that the augmentation of autophagy (though sirtuin-1) and suppression of inflammation by olive polyphenols could contribute to the chondroprotective effects of olive polyphenols. More research and well-planned clinical trials are required to justify the use of olive-based treatment in osteoarthritis.

Original languageEnglish
Article number1060
JournalNutrients
Volume9
Issue number10
DOIs
Publication statusPublished - 26 Sep 2017

Fingerprint

osteoarthritis
Olea
Therapeutic Uses
Osteoarthritis
therapeutics
autophagy
Autophagy
inflammation
chondrocytes
Polyphenols
Chondrocytes
Inflammation
polyphenols
Sirtuin 1
joints (animal)
cartilage
in vitro studies
Cartilage
morbidity
clinical trials

Keywords

  • Autophagy
  • Cartilage
  • Chondrocyte
  • Hydroxytyrosol
  • Inflammation
  • Joint
  • Oleocanthal
  • Oleuropein
  • Sirtuin-1
  • Tyrosol

ASJC Scopus subject areas

  • Food Science

Cite this

Therapeutic effects of olive and its derivatives on osteoarthritis : From bench to bedside. / Kok Yong, Chin; Pang, Kok Lun.

In: Nutrients, Vol. 9, No. 10, 1060, 26.09.2017.

Research output: Contribution to journalReview article

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