The value of 18F-fluorodeoxyglucose PET (18F-FDG PET) and MRI spectroscopy in underpinning suspicious breast cancer

S. Shazreen, R. Shakher, Shahrun Niza Abdullah Suhaimi, A. S. Fathinul Fikri

Research output: Contribution to journalArticle

Abstract

The aim of this study was to evaluate the value of MRI spectroscopy and association with the altered glucose metabolism on 18-FDG PET/CT in patients with suspicious breast cancer. Eight selected breast cancer patients with BIRADS 4 or 5 on mammogram were recruited and patients underwent 18F-FDG PET/CT MRI (spectroscopy). The standardise uptake value (SUVmax) was analysed to determine the degree of the altered glucose metabolism on the PET. The metabolites of tumor lesions were measured using in vivo proton MR spectroscopy (MRS) of the breast. There were eight females with a mean age of 55.3±12.2 years with a biopsy result of invasive ductal carcinoma (2), lobular carcinoma (1) and benign lesion (5). There was a significant difference between the mean of the malignant tumour (SUVmax 4.28±3.74 g/ml) and the mean of the benign tumour (SUVmax: 2.33±0.9 g/ml). On the per-lesional basis of the MRS correlate with SUVmax, the suspicious breast tissue exhibited raised creatinine metabolites (mean: 3.39±0.54u) with significant correlation SUVmax mean 3.06±2.34 as compared to N-acetyl Aspartate (NAA), (mean: 2.84±0.99u) and choline (mean: 2.46± 0.70 u). This study showed that high SUVmax was associated with malignant cancer and the high creatinine metabolite that correlated with the SUVmax could potentially be utilised as a surrogate marker in detecting breast cancer.

Original languageEnglish
Pages (from-to)225-234
Number of pages10
JournalPertanika Journal of Science and Technology
Volume26
Issue number1
Publication statusPublished - 1 Jan 2018

Fingerprint

Fluorodeoxyglucose F18
breast neoplasms
Magnetic resonance imaging
spectroscopy
cancer
Spectrum Analysis
Metabolites
tumor
Spectroscopy
Breast Neoplasms
Tumors
metabolite
neoplasms
metabolites
Metabolism
lesion
creatinine
breasts
carcinoma
Glucose

Keywords

  • Computed tomography
  • Magnetic resonances imaging spectroscopy
  • Multimodality
  • Positron emission tomography
  • [18F]-fluorodeoxyglucose

ASJC Scopus subject areas

  • Computer Science(all)
  • Chemical Engineering(all)
  • Environmental Science(all)
  • Agricultural and Biological Sciences(all)

Cite this

The value of 18F-fluorodeoxyglucose PET (18F-FDG PET) and MRI spectroscopy in underpinning suspicious breast cancer. / Shazreen, S.; Shakher, R.; Abdullah Suhaimi, Shahrun Niza; Fathinul Fikri, A. S.

In: Pertanika Journal of Science and Technology, Vol. 26, No. 1, 01.01.2018, p. 225-234.

Research output: Contribution to journalArticle

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