The use of umbelliferone in the synthesis of new heterocyclic compounds

Ahmed A. Al-Amiery, Ahmed Y. Musa, Abdul Amir H. Kadhum, Abu Bakar Mohamad

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

New coumarin derivatives, namely 7-[(5-amino-1,3,4-thiadiazol-2-yl)methoxy] - 2H-chromen-2-one (4), 5-[(2-oxo-2H-chromen-7-yloxy)methyl]-1,3,4-thiadiazol- 2(3H)- one (5), 2-[2-(2-oxo-2H-chromen-7-yloxy)acetyl]-N- phenylhydrazinecarbothioamide (7), 7-[(5-(phenylamino)-1,3,4-thiadiazol-2-yl) methoxy]-2H-chromen-2-one (8) and 7-[(5- mercapto-4-phenyl-4H-1,2,4-triazol-3- yl)methoxy]-2H-chromen-2-one (9) were prepared starting from the natural compound umbelliferone (1). The newly synthesized compounds were characterized by elemental analysis and spectral studies (IR, 1H-NMR and 13C-NMR).

Original languageEnglish
Pages (from-to)6833-6843
Number of pages11
JournalMolecules
Volume16
Issue number8
DOIs
Publication statusPublished - Aug 2011

Fingerprint

7-hydroxycoumarin
Heterocyclic Compounds
heterocyclic compounds
Coumarins
Nuclear magnetic resonance
nuclear magnetic resonance
synthesis
Chemical analysis
Carbon-13 Magnetic Resonance Spectroscopy
8-methoxychromen-2-one
Proton Magnetic Resonance Spectroscopy

Keywords

  • 1,3,4-thiadiazole
  • Coumarin
  • Ethyl bromoacetate
  • Phosphorous oxychloride
  • Thiosemicarbazide
  • Umbelliferone

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Al-Amiery, A. A., Musa, A. Y., Kadhum, A. A. H., & Mohamad, A. B. (2011). The use of umbelliferone in the synthesis of new heterocyclic compounds. Molecules, 16(8), 6833-6843. https://doi.org/10.3390/molecules16086833

The use of umbelliferone in the synthesis of new heterocyclic compounds. / Al-Amiery, Ahmed A.; Musa, Ahmed Y.; Kadhum, Abdul Amir H.; Mohamad, Abu Bakar.

In: Molecules, Vol. 16, No. 8, 08.2011, p. 6833-6843.

Research output: Contribution to journalArticle

Al-Amiery, AA, Musa, AY, Kadhum, AAH & Mohamad, AB 2011, 'The use of umbelliferone in the synthesis of new heterocyclic compounds', Molecules, vol. 16, no. 8, pp. 6833-6843. https://doi.org/10.3390/molecules16086833
Al-Amiery, Ahmed A. ; Musa, Ahmed Y. ; Kadhum, Abdul Amir H. ; Mohamad, Abu Bakar. / The use of umbelliferone in the synthesis of new heterocyclic compounds. In: Molecules. 2011 ; Vol. 16, No. 8. pp. 6833-6843.
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