The use of selective estrogen receptor modulators on bone health in men

Sok Kuan Wong, Nur Vaizura Mohamad, Putri Ayu Jayusman, Ahmad Nazrun Shuid, Ima Nirwana Soelaiman, Chin Kok Yong

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Selective estrogen receptor modulators (SERMs) represent a class of drugs that act as agonist or antagonist for estrogen receptor in a tissue-specific manner. The SERMs drugs are initially used for the prevention and treatment of osteoporosis in postmenopausal women. Bone health in prostate cancer patients has become a significant concern, whereby patients undergo androgen deprivation therapy is often associated with deleterious effects on bone. Previous preclinical and epidemiological findings showed that estrogens play a dominant role in improving bone health as compared to testosterone in men. Therefore, this evidence-based review aims to assess the available evidence derived from animal and human studies on the effects of SERMs on the male skeletal system. The effects of SERMs on bone mineral density (BMD)/content (BMC), bone histomorphometry, bone turnover, bone strength and fracture risk have been summarized in this review.

Original languageEnglish
Pages (from-to)89-101
Number of pages13
JournalAging Male
Volume22
Issue number2
DOIs
Publication statusPublished - 3 Apr 2019

Fingerprint

Men's Health
Selective Estrogen Receptor Modulators
Bone and Bones
Bone Density
Postmenopausal Osteoporosis
Bone Remodeling
Bone Fractures
Health
Pharmaceutical Preparations
Androgens
Testosterone
Prostatic Neoplasms
Estrogens
Therapeutics

Keywords

  • lasofoxifene
  • Osteoporosis
  • raloxifene
  • tamoxifen
  • toremifene

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

The use of selective estrogen receptor modulators on bone health in men. / Wong, Sok Kuan; Mohamad, Nur Vaizura; Jayusman, Putri Ayu; Shuid, Ahmad Nazrun; Soelaiman, Ima Nirwana; Kok Yong, Chin.

In: Aging Male, Vol. 22, No. 2, 03.04.2019, p. 89-101.

Research output: Contribution to journalReview article

Wong, Sok Kuan ; Mohamad, Nur Vaizura ; Jayusman, Putri Ayu ; Shuid, Ahmad Nazrun ; Soelaiman, Ima Nirwana ; Kok Yong, Chin. / The use of selective estrogen receptor modulators on bone health in men. In: Aging Male. 2019 ; Vol. 22, No. 2. pp. 89-101.
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