The use of Piper sarmentosum leaves aqueous extract (Kadukmy™) as antihypertensive agent in spontaneous hypertensive rats

Maizura Mohd Zainudin, Zaiton Zakaria, Nor Anita Megat Mohd Nordin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

BACKGROUND: The National Health and Morbidity Survey in 2011 estimated that 35.1% (5.7 million) of Malaysian adults aged 18 and older suffer from hypertension. Hypertension is still treated by conventional medicine despite its exact aetiology being unknown. Studies showed that oxidative stress and low availability of nitric oxide (NO) causes an increase in vascular wall tension and increase blood pressure. Piper sarmentosum (PS) a traditional Malay herbal plant is well known for its high antioxidant content. Antioxidant is useful in improving cardiovascular diseases particularly hypertension. Thus, it is beneficial to determine the effect of PS leaves aqueous extract (Kadukmy™) on the blood pressure, NO level, oxidative stress markers and serum cholesterol level of the Spontaneous Hypertensive Rats (SHR).

METHODS: Rats were devided into five groups consisting of three treatment groups and two control groups. Baseline blood investigations were done before and following commencement of treatment. Spontaneous hypertensive rats were treated for 28 consecutive days and the blood pressure was measured weekly.

RESULTS: Kadukmy™ administration showed a significant reduction in systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP) (P 

CONCLUSIONS: The result of the present study revealed that Kadukmy™ exerts its antioxidant activity to reduce oxidative stress damage, increase NO production and able to reduce blood pressure and cholesterol level.

Original languageEnglish
Pages (from-to)54
Number of pages1
JournalBMC Complementary and Alternative Medicine
Volume15
DOIs
Publication statusPublished - 2015

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Piper
Antihypertensive Agents
Blood Pressure
Nitric Oxide
Oxidative Stress
Antioxidants
Hypertension
Cholesterol
Health Surveys
Blood Vessels
Arterial Pressure
Cardiovascular Diseases
Biomarkers
Medicine
Morbidity
Control Groups

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The use of Piper sarmentosum leaves aqueous extract (Kadukmy™) as antihypertensive agent in spontaneous hypertensive rats. / Mohd Zainudin, Maizura; Zakaria, Zaiton; Megat Mohd Nordin, Nor Anita.

In: BMC Complementary and Alternative Medicine, Vol. 15, 2015, p. 54.

Research output: Contribution to journalArticle

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