The supplementation of levothyroxine among indigenous people in endemic goitre areas: The impact of therapy

Zaleha Md Isa, A. Osman, Z. A. Iskandar, S. Sazali, M. Muhammad Ali, I. Roslan, B. A K Khalid

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In order to study the effect of levothyroxine in the treatment of endemic goitre, a longitudinal study was conducted among the Aborigines in Lanai Post and Sinderut Post, situated in an iodine-deficient area located in the district of Kuala Lipis, Pahang. All subjects in the treatment group (Lanai Post) were given 100 μg of levothyroxine per day and were followed for 11/2 years. A total of 311 subjects were examined at baseline, 323 on the first, 256 on the second, 239 on the third and 184 on the fourth visit following levothyroxine supplementation. Goitre prevalence, thyroid hormones, thyroid volume, nutritional status, urinary iodine levels, arterial blood pressure and mental performance were determined. Following the intervention, goitre prevalence was significantly reduced in the treatment group (baseline 42.8% vs final visit 13.0%, P < 0.0001); however, no significant difference was noted in the control group. Total T4 levels were increased in the treatment group (P < 0.0001), while a significant reduction was noted in the control group (P < 0.0001). Thyroid-stimulating hormone levels increased significantly in the treatment group following 1 year of intervention, while no significant changes were observed in the control group. As for the thyroid volume, both groups showed a significant increment following the intervention (P < 0.0001). With respect to the nutritional status, the treatment group showed a significant increase in body weight following the intervention (P < 0.05). In addition, the mid-arm circumference and body mass index also increased after 1 year of intervention. However, the control group showed a reduction in the waist-hip ratio (P < 0.0001). Although there was no statistical difference in the waist-hip ratio in the treatment group, there has been a significant reduction observed after 1 year of intervention. At 1 year, a reduction in skinfold thickness was noted in the treatment group while only the triceps and subscapular were increased in the control group. The body fat was decreased in the treatment group following 1 year of intervention (P < 0.0001). No particular trend was noted in the urinary iodine excretion in the treatment group, but surprisingly, the levels were increased in the control group (P < 0.0001). A significant increase in both systolic and diastolic blood pressures was observed in the treatment group following 1 year of intervention, but the controls showed a reduction in the systolic blood pressure (P < 0.0001). Both groups showed a remarkable increase in mental performance, with a more pronounced effect in the treatment group (P < 0.05). The correction of iodine deficiency by levothyroxine supplementation has a short-term beneficial effect in reducing the prevalence of goitre and improving the mental ability among the Aborigines in endemic areas; however, proper monitoring and close supervision are needed to maintain compliance.

Original languageEnglish
Pages (from-to)138-150
Number of pages13
JournalAsia Pacific Journal of Clinical Nutrition
Volume7
Issue number2
Publication statusPublished - 1998

Fingerprint

Endemic Goiter
Thyroxine
Iodine
Control Groups
Goiter
Blood Pressure
Waist-Hip Ratio
Nutritional Status
Thyroid Gland
Therapeutics
Skinfold Thickness
Thyrotropin
Thyroid Hormones
Compliance
Longitudinal Studies
Adipose Tissue
Arterial Pressure
Body Mass Index
Body Weight

Keywords

  • Aborigines
  • Goitre
  • Indigenous people
  • Iodine deficiency
  • Levothyroxine
  • Malaysia

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Md Isa, Z., Osman, A., Iskandar, Z. A., Sazali, S., Ali, M. M., Roslan, I., & Khalid, B. A. K. (1998). The supplementation of levothyroxine among indigenous people in endemic goitre areas: The impact of therapy. Asia Pacific Journal of Clinical Nutrition, 7(2), 138-150.

The supplementation of levothyroxine among indigenous people in endemic goitre areas : The impact of therapy. / Md Isa, Zaleha; Osman, A.; Iskandar, Z. A.; Sazali, S.; Ali, M. Muhammad; Roslan, I.; Khalid, B. A K.

In: Asia Pacific Journal of Clinical Nutrition, Vol. 7, No. 2, 1998, p. 138-150.

Research output: Contribution to journalArticle

Md Isa, Z, Osman, A, Iskandar, ZA, Sazali, S, Ali, MM, Roslan, I & Khalid, BAK 1998, 'The supplementation of levothyroxine among indigenous people in endemic goitre areas: The impact of therapy', Asia Pacific Journal of Clinical Nutrition, vol. 7, no. 2, pp. 138-150.
Md Isa, Zaleha ; Osman, A. ; Iskandar, Z. A. ; Sazali, S. ; Ali, M. Muhammad ; Roslan, I. ; Khalid, B. A K. / The supplementation of levothyroxine among indigenous people in endemic goitre areas : The impact of therapy. In: Asia Pacific Journal of Clinical Nutrition. 1998 ; Vol. 7, No. 2. pp. 138-150.
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