The SAFE (SGRQ score, air-flow limitation and exercise tolerance) Index

A new composite score for the stratification of severity in chronic obstructive pulmonary disease

Mohd Shah Azarisman, Mohd Anshar Fauzi, Mohd Perdaus Ahmad Faizal, Azami Zaharim, Roslina Abd. Manap, Harun Roslan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background: This study was proposed to develop a composite of outcome measures using forced expiratory volume percentage of predicted, exercise capacity and quality of life scores for assessment of chronic obstructive pulmonary disease (COPD) severity. Materials and methods: Eighty-six patients with COPD were enrolled into a prospective, observational study at the respiratory outpatient clinic, National University Hospital Malaysia (Hospital Universiti Kebangsaan Malaysia - HUKM), Kuala Lumpur. Results: Our study found modest correlation between the forced expiratory volume in 1 s (FEV 1), 6 min walk distance and the SGRQ scores with mean (SD) values of 0.97 (0.56) litres/s, 322 (87) m and 43.7 (23.6)%, respectively. K-Means cluster analysis identified four distinct clusters which reached statistical significance which was refined to develop a new cumulative staging system. The SAFE Index score correlated with the number of exacerbations in 2 years (r = 0.497, p<0.001). Conclusion: We have developed the SGRQ, Air-Flow limitation and Exercise tolerance Index (SAFE Index) for the stratification of severity in COPD. This index incorporates the SGRQ score, the FEV1 % predicted and the 6 min walk distance. The SAFE Index is moderately correlated with the number of disease exacerbations.

Original languageEnglish
Pages (from-to)492-497
Number of pages6
JournalPostgraduate Medical Journal
Volume83
Issue number981
DOIs
Publication statusPublished - Jul 2007

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Exercise Tolerance
Chronic Obstructive Pulmonary Disease
Malaysia
Air
Forced Expiratory Volume
Ambulatory Care Facilities
Observational Studies
Cluster Analysis
Disease Progression
Quality of Life
Outcome Assessment (Health Care)
Prospective Studies
Exercise

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The SAFE (SGRQ score, air-flow limitation and exercise tolerance) Index : A new composite score for the stratification of severity in chronic obstructive pulmonary disease. / Azarisman, Mohd Shah; Fauzi, Mohd Anshar; Faizal, Mohd Perdaus Ahmad; Zaharim, Azami; Abd. Manap, Roslina; Roslan, Harun.

In: Postgraduate Medical Journal, Vol. 83, No. 981, 07.2007, p. 492-497.

Research output: Contribution to journalArticle

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