The role of zinc in genomic stability

Razinah Sharif @ Mohd Sharif, Philip Thomas, Peter Zalewski, Michael Fenech

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

Zinc (Zn) is an essential trace element required for maintaining both optimal human health and genomic stability. Zn plays a critical role in the regulation of DNA repair mechanisms, cell proliferation, differentiation and apoptosis involving the action of various transcriptional factors and DNA or RNA polymerases. Zn is an essential cofactor or structural component for important antioxidant defence proteins and DNA repair enzymes such as Cu/Zn SOD, OGG1, APE and PARP and may also affect activities of enzymes such as BHMT and MTR involved in methylation reactions in the folate-methionine cycle. This review focuses on the role of Zn in the maintenance of genome integrity and the effects of deficiency or excess on genomic stability events and cell death.

Original languageEnglish
Pages (from-to)111-121
Number of pages11
JournalMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
Volume733
Issue number1-2
DOIs
Publication statusPublished - 1 May 2012

Fingerprint

Genomic Instability
Zinc
DNA Repair Enzymes
Trace Elements
DNA-Directed DNA Polymerase
DNA-Directed RNA Polymerases
Folic Acid
DNA Repair
Methionine
Methylation
Cell Differentiation
Cell Death
Antioxidants
Maintenance
Cell Proliferation
Genome
Apoptosis
Health
Enzymes
Proteins

Keywords

  • DNA damage
  • Genomic stability
  • Methylation
  • Micronuclei
  • Telomere
  • Zinc

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

The role of zinc in genomic stability. / Sharif @ Mohd Sharif, Razinah; Thomas, Philip; Zalewski, Peter; Fenech, Michael.

In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Vol. 733, No. 1-2, 01.05.2012, p. 111-121.

Research output: Contribution to journalArticle

Sharif @ Mohd Sharif, Razinah ; Thomas, Philip ; Zalewski, Peter ; Fenech, Michael. / The role of zinc in genomic stability. In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2012 ; Vol. 733, No. 1-2. pp. 111-121.
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