The role of urinary neutrophil gelatinase-associated lipocalin in lupus nephritis

Sabah Mohamed Alharazy, Norella C T Kong, Marlyn Mohd, Shamsul Azhar Shah, Abdul Halim Abdul Gafor, Arbaiyah BaD́in

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Urine neutrophil gelatinase-associated lipocalin (uNGAL) has been proposed as a potential biomarker for lupus nephritis (LN) activity. We determined the association between uNGAL with LN activity in systemic lupus erythematosus (SLE) patients compared to the current standard markers of SLE. Methods: A total of 100 SLE patients with biopsy-proven LN were recruited-47 with active and 53 inactive LN. uNGAL levels were measured. Renal function test, urinary parameters, lupus serology and calculated renal SLE Disease Activity Index-2K (renal SLEDAI-2K) were analyzed to determine their associations with uNGAL. Results: Normalized uNGAL levels (ng/mg creatinine) were significantly higher in patients with active LN compared to those with inactive disease (p. = 0.01). uNGAL and renal SLEDAI-2K were associated (r. = 0.32, p. = 0.001). Multiple logistic regression showed that only serum creatinine and renal SLEDAI-2K were independent predictors of uNGAL levels (p. = 0.03 and 0.02 respectively). Analysis of the receiver operating characteristic (ROC) curve showed that uNGAL was a potential biomarker for LN. Conclusions: uNGAL was increased in active LN especially in LN flares. Serial measurements of uNGAL levels may be of value in monitoring response of LN to treatment and for predicting LN flares.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalClinica Chimica Acta
Volume425
DOIs
Publication statusPublished - 1 Oct 2013

Fingerprint

Lipocalins
Gelatinases
Lupus Nephritis
Urine
Systemic Lupus Erythematosus
Kidney
Biomarkers
Creatinine
Lipocalin-2
Biopsy
Serology
ROC Curve
Logistics
Logistic Models
Association reactions

Keywords

  • Lupus nephritis
  • Renal disease activity
  • Urine neutrophil gelatinase-associated lipocalin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

The role of urinary neutrophil gelatinase-associated lipocalin in lupus nephritis. / Alharazy, Sabah Mohamed; Kong, Norella C T; Mohd, Marlyn; Shah, Shamsul Azhar; Abdul Gafor, Abdul Halim; BaD́in, Arbaiyah.

In: Clinica Chimica Acta, Vol. 425, 01.10.2013, p. 163-168.

Research output: Contribution to journalArticle

Alharazy, Sabah Mohamed ; Kong, Norella C T ; Mohd, Marlyn ; Shah, Shamsul Azhar ; Abdul Gafor, Abdul Halim ; BaD́in, Arbaiyah. / The role of urinary neutrophil gelatinase-associated lipocalin in lupus nephritis. In: Clinica Chimica Acta. 2013 ; Vol. 425. pp. 163-168.
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