The role of tyrosine hydroxylase gene variants in suicide attempt in schizophrenia

Jiayi Hu, Lai Fong Chan, Renan P. Souza, Maria Tampakeras, James L. Kennedy, Clement Zai, Vincenzo De Luca

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Evidence has shown that attempted suicide in psychiatric disorders is a complex interplay of genes and environment. Noradrenergic dysfunction due to abnormalities in the tyrosine hydroxylase (TH) gene has been implicated in the pathogenesis of suicidal behavior in mood disorders. However, suicide is a leading cause of mortality in schizophrenia too. Recent evidence suggests that TH gene variants may also increase the risk of suicide attempts in schizophrenia patients, although the interaction with established clinical risk factors is unclear. This study aimed to identify TH gene variants conferring risk for suicide attempt in schizophrenia while accounting for the interaction between this gene and clinical risk factors. We performed analysis on four TH SNPs (rs11564717, rs11042950, rs2070762, rs689) and the common TCAT repeat (UniSTS:240639) for 234 schizophrenia patients (51 suicide attempters and 183 non-attempters). Clinical risk factors and ethnic stratification were included as covariates. Single marker analysis identified the SNP rs11564717 (p=0.042) and the TCAT(6) (p=0.004) as risk variants for suicide attempt. We also identified the haplotype A-A-A-G as a risk factor for suicide attempt (p=0.0025). In conclusion, our findings suggest that TH polymorphisms may contribute to the risk of attempted suicide in schizophrenia even after accounting for established clinical risk factors and ethnic stratification. Further larger scale studies are needed to confirm these findings and to understand the mechanisms underlying the role of TH gene variants in suicide attempt in schizophrenia.

Original languageEnglish
Pages (from-to)39-43
Number of pages5
JournalNeuroscience Letters
Volume559
DOIs
Publication statusPublished - 24 Jan 2014

Fingerprint

Tyrosine 3-Monooxygenase
Suicide
Schizophrenia
Genes
Attempted Suicide
Single Nucleotide Polymorphism
Mood Disorders
Haplotypes
Psychiatry
Mortality

Keywords

  • Clinical risk factors
  • Schizophrenia
  • Suicide attempt
  • Tyrosine hydroxylase gene

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The role of tyrosine hydroxylase gene variants in suicide attempt in schizophrenia. / Hu, Jiayi; Chan, Lai Fong; Souza, Renan P.; Tampakeras, Maria; Kennedy, James L.; Zai, Clement; De Luca, Vincenzo.

In: Neuroscience Letters, Vol. 559, 24.01.2014, p. 39-43.

Research output: Contribution to journalArticle

Hu, Jiayi ; Chan, Lai Fong ; Souza, Renan P. ; Tampakeras, Maria ; Kennedy, James L. ; Zai, Clement ; De Luca, Vincenzo. / The role of tyrosine hydroxylase gene variants in suicide attempt in schizophrenia. In: Neuroscience Letters. 2014 ; Vol. 559. pp. 39-43.
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