The role of proton pump inhibitors in adenoid hypertrophy in children

Farim Rizal Wong Iqbal, Bee See Goh, Ami Mazita

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objectives. To establish the efficacy of proton pump inhibitors (PPI) in the treatment of adenoid hypertrophy in children. Design. Randomized controlled double-blinded clinical trial. Population. Forty children, aged 2 to 12 years, with adenoid hypertrophy fulfilling the inclusion and exclusion criteria. Methods. Patients were randomly allocated into 2 groups: one to be treated with oral Losec MUPS for a period of 2 months (treatment group) and the other to be given a low-dose vitamin C tablet for the same period (control group). The patients were reviewed on 2 occasions during the 2-month study period, during which endoscopy was performed to examine the adenoid glands to assess their size and the larynx to assess signs of reflux disease. Examination of tonsillar size was also performed. Results. There was a significant reduction in adenoid size in the treatment group, but the control group also demonstrated a significant reduction in adenoid size. Comparison between the 2 groups in terms of adenoid grade change between the first and second visits did not reveal any significant statistical difference. Conclusion. The results of this study do not demonstrate any efficacy of PPIs for adenoid hypertrophy in children, and these drugs should not be used for this purpose.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalOtolaryngology - Head and Neck Surgery (United States)
Volume147
Issue number2
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Adenoids
Proton Pump Inhibitors
Hypertrophy
Control Groups
Larynx
Endoscopy
Tablets
Ascorbic Acid
Therapeutics
Clinical Trials
Pharmaceutical Preparations
Population

Keywords

  • adenoid hypertrophy
  • proton pump inhibitors

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Surgery
  • Medicine(all)

Cite this

The role of proton pump inhibitors in adenoid hypertrophy in children. / Iqbal, Farim Rizal Wong; Goh, Bee See; Mazita, Ami.

In: Otolaryngology - Head and Neck Surgery (United States), Vol. 147, No. 2, 08.2012, p. 329-334.

Research output: Contribution to journalArticle

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