The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review)

Hawa N. Siti, Kamisah Yusof, Kamsiah Jaarin

Research output: Contribution to journalArticle

275 Citations (Scopus)

Abstract

The concept of mild chronic vascular inflammation as part of the pathophysiology of cardiovascular disease, most importantly hypertension and atherosclerosis, has been well accepted. Indeed there are links between vascular inflammation, endothelial dysfunction and oxidative stress. However, there are still gaps in our understanding regarding this matter that might be the cause behind disappointing results of antioxidant therapy for cardiovascular risk factors in large-scale long-term randomised controlled trials. Apart from the limitations of our knowledge, limitations in methodology and assessment of the body's endogenous and exogenous oxidant-antioxidant status are a serious handicap. The pleiotropic effects of antioxidant and anti-inflammation that are shown by some well-established antihypertensive agents and statins partly support the idea of using antioxidants in vascular diseases as still relevant. This review aims to provide an overview of the links between oxidative stress, vascular inflammation, endothelial dysfunction and cardiovascular risk factors, importantly focusing on blood pressure regulation and atherosclerosis. In view of the potential benefits of antioxidants, this review will also examine the proposed role of vitamin C, vitamin E and polyphenols in cardiovascular diseases as well as the success or failure of antioxidant therapy for cardiovascular diseases in clinical trials.

Original languageEnglish
Pages (from-to)40-56
Number of pages17
JournalVascular Pharmacology
Volume71
DOIs
Publication statusPublished - 1 Aug 2015

Fingerprint

Blood Vessels
Oxidative Stress
Cardiovascular Diseases
Antioxidants
Inflammation
Atherosclerosis
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Polyphenols
Vitamin E
Vascular Diseases
Oxidants
Antihypertensive Agents
Ascorbic Acid
Randomized Controlled Trials
Clinical Trials
Blood Pressure
Hypertension
Therapeutics

Keywords

  • Antioxidant
  • Atherosclerosis
  • Hypertension
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine
  • Physiology

Cite this

The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). / Siti, Hawa N.; Yusof, Kamisah; Jaarin, Kamsiah.

In: Vascular Pharmacology, Vol. 71, 01.08.2015, p. 40-56.

Research output: Contribution to journalArticle

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