The risk and associated factors of methamphetamine psychosis in methamphetamine-dependent patients in Malaysia

Ahmad Hatim Sulaiman, Mas Ayu Said, Mohd Hussain Habil, Rusdi Rashid, Amer Siddiq, Ng Chong Guan, Marhani Midin, Nik Ruzyanei Nik Jaafar, Hatta Sidi, Srijit Das

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Abstract

Objective The objective of this study was to determine the risk of lifetime and current methamphetamine-induced psychosis in patients with methamphetamine dependence. The association between psychiatric co-morbidity and methamphetamine-induced psychosis was also studied. Methods This was a cross-sectional study conducted concurrently at a teaching hospital and a drug rehabilitation center in Malaysia. Patients with the diagnosis of methamphetamine based on DSM-IV were interviewed using the Mini International Neuropsychiatric Interview (M.I.N.I.) for methamphetamine-induced psychosis and other Axis I psychiatric disorders. The information on sociodemographic background and drug use history was obtained from interview or medical records. Results Of 292 subjects, 47.9% of the subjects had a past history of psychotic symptoms and 13.0% of the patients were having current psychotic symptoms. Co-morbid major depressive disorder (OR = 7.18, 95 CI = 2.612-19.708), bipolar disorder (OR = 13.807, 95 CI = 5.194-36.706), antisocial personality disorder (OR = 12.619, 95 CI = 6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors. Major depressive disorder (OR = 2.870, CI = 1.154-7.142) and antisocial personality disorder (OR = 3.299, 95 CI = 1.375-7.914) were the only factors associated with current psychosis. Conclusion There was a high risk of psychosis in patients with methamphetamine dependence. It was associated with co-morbid affective disorder, antisocial personality, and heavy methamphetamine use. It is recommended that all cases of methamphetamine dependence should be screened for psychotic symptoms.

Original languageEnglish
JournalComprehensive Psychiatry
Volume55
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Jan 2014

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Methamphetamine
Malaysia
Psychotic Disorders
Antisocial Personality Disorder
Major Depressive Disorder
Psychiatry
Substance Abuse Treatment Centers
Interviews
Mood Disorders
Bipolar Disorder
Teaching Hospitals
Diagnostic and Statistical Manual of Mental Disorders
Medical Records
Cross-Sectional Studies
Morbidity

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Psychology

Cite this

The risk and associated factors of methamphetamine psychosis in methamphetamine-dependent patients in Malaysia. / Sulaiman, Ahmad Hatim; Said, Mas Ayu; Habil, Mohd Hussain; Rashid, Rusdi; Siddiq, Amer; Guan, Ng Chong; Midin, Marhani; Nik Jaafar, Nik Ruzyanei; Sidi, Hatta; Das, Srijit.

In: Comprehensive Psychiatry, Vol. 55, No. SUPPL. 1, 01.2014.

Research output: Contribution to journalArticle

Sulaiman, Ahmad Hatim ; Said, Mas Ayu ; Habil, Mohd Hussain ; Rashid, Rusdi ; Siddiq, Amer ; Guan, Ng Chong ; Midin, Marhani ; Nik Jaafar, Nik Ruzyanei ; Sidi, Hatta ; Das, Srijit. / The risk and associated factors of methamphetamine psychosis in methamphetamine-dependent patients in Malaysia. In: Comprehensive Psychiatry. 2014 ; Vol. 55, No. SUPPL. 1.
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AU - Siddiq, Amer

AU - Guan, Ng Chong

AU - Midin, Marhani

AU - Nik Jaafar, Nik Ruzyanei

AU - Sidi, Hatta

AU - Das, Srijit

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N2 - Objective The objective of this study was to determine the risk of lifetime and current methamphetamine-induced psychosis in patients with methamphetamine dependence. The association between psychiatric co-morbidity and methamphetamine-induced psychosis was also studied. Methods This was a cross-sectional study conducted concurrently at a teaching hospital and a drug rehabilitation center in Malaysia. Patients with the diagnosis of methamphetamine based on DSM-IV were interviewed using the Mini International Neuropsychiatric Interview (M.I.N.I.) for methamphetamine-induced psychosis and other Axis I psychiatric disorders. The information on sociodemographic background and drug use history was obtained from interview or medical records. Results Of 292 subjects, 47.9% of the subjects had a past history of psychotic symptoms and 13.0% of the patients were having current psychotic symptoms. Co-morbid major depressive disorder (OR = 7.18, 95 CI = 2.612-19.708), bipolar disorder (OR = 13.807, 95 CI = 5.194-36.706), antisocial personality disorder (OR = 12.619, 95 CI = 6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors. Major depressive disorder (OR = 2.870, CI = 1.154-7.142) and antisocial personality disorder (OR = 3.299, 95 CI = 1.375-7.914) were the only factors associated with current psychosis. Conclusion There was a high risk of psychosis in patients with methamphetamine dependence. It was associated with co-morbid affective disorder, antisocial personality, and heavy methamphetamine use. It is recommended that all cases of methamphetamine dependence should be screened for psychotic symptoms.

AB - Objective The objective of this study was to determine the risk of lifetime and current methamphetamine-induced psychosis in patients with methamphetamine dependence. The association between psychiatric co-morbidity and methamphetamine-induced psychosis was also studied. Methods This was a cross-sectional study conducted concurrently at a teaching hospital and a drug rehabilitation center in Malaysia. Patients with the diagnosis of methamphetamine based on DSM-IV were interviewed using the Mini International Neuropsychiatric Interview (M.I.N.I.) for methamphetamine-induced psychosis and other Axis I psychiatric disorders. The information on sociodemographic background and drug use history was obtained from interview or medical records. Results Of 292 subjects, 47.9% of the subjects had a past history of psychotic symptoms and 13.0% of the patients were having current psychotic symptoms. Co-morbid major depressive disorder (OR = 7.18, 95 CI = 2.612-19.708), bipolar disorder (OR = 13.807, 95 CI = 5.194-36.706), antisocial personality disorder (OR = 12.619, 95 CI = 6.702-23.759) and heavy methamphetamine uses were significantly associated with lifetime methamphetamine-induced psychosis after adjusted for other factors. Major depressive disorder (OR = 2.870, CI = 1.154-7.142) and antisocial personality disorder (OR = 3.299, 95 CI = 1.375-7.914) were the only factors associated with current psychosis. Conclusion There was a high risk of psychosis in patients with methamphetamine dependence. It was associated with co-morbid affective disorder, antisocial personality, and heavy methamphetamine use. It is recommended that all cases of methamphetamine dependence should be screened for psychotic symptoms.

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