The remarkable three-dimensional network structure of bacterial cellulose for tissue engineering applications

Nadia Halib, Ishak Ahmad, Mario Grassi, Gabriele Grassi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cellulose is a natural homopolymer, composed of β-1,4- anhydro-D-glucopyranose units. Unlike plant cellulose, bacterial cellulose (BC), obtained from species belonging to the genera of Acetobacter, Rhizobium, Agrobacterium, and Sarcina through various cultivation methods and techniques, is produced in its pure form. BC is produced in the form of gel-like, never dry sheet with tremendous mechanical properties. Containing up to 99% of water, BC hydrogel is considered biocompatible thus finding robust applications in the health industry. Moreover, BC three-dimensional structure closely resembles the extracellular matrix (ECM) of living tissue. In this review, we focus on the porous BC morphology particularly suited to host oxygen and nutrients thus providing conducive environment for cell growth and proliferation. The remarkable BC porous morphology makes this biological material a promising templet for the generation of 3D tissue culture and possibly for tissue-engineered scaffolds.

Original languageEnglish
Pages (from-to)631-640
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume566
DOIs
Publication statusPublished - 20 Jul 2019

Fingerprint

Bacterial Structures
Tissue Engineering
Cellulose
Sarcina
Acetobacter
Tissue Scaffolds
Agrobacterium
Rhizobium
Hydrogel
Extracellular Matrix
Industry
Gels
Cell Proliferation
Oxygen
Food
Water
Health

Keywords

  • 3D tissue culture
  • Bacterial cellulose
  • Extracellular matrix
  • Tissue scaffolds

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

The remarkable three-dimensional network structure of bacterial cellulose for tissue engineering applications. / Halib, Nadia; Ahmad, Ishak; Grassi, Mario; Grassi, Gabriele.

In: International Journal of Pharmaceutics, Vol. 566, 20.07.2019, p. 631-640.

Research output: Contribution to journalArticle

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