The relevance of polymeric synthetic membranes in topical formulation assessment and drug diffusion study

Shiow Fern Ng, Jennifer J. Rouse, Francis D. Sanderson, Gillian M. Eccleston

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Synthetic membranes are composed of thin sheets of polymeric macromolecules that can control the passage of components through them. Generally, synthetic membranes used in drug diffusion studies have one of two functions: skin simulation or quality control. Synthetic membranes for skin simulation, such as the silicone-based membranes polydimethylsiloxane and Carbosil', are generally hydrophobic and rate limiting, imitating the stratum corneum. In contrast, synthetic membranes for quality control, such as cellulose esters and polysulfone, are required to act as a support rather than a barrier. These synthetic membranes also often contain pores; hence, they are called porous membranes. The significance of Franz diffusion studies and synthetic membranes in quality control studies involves an understanding of the fundamentals of synthetic membranes. This article provides a general overview of synthetic membranes, including a brief background of the history and the common applications of synthetic membranes. This review then explores the types of synthetic membranes, the transport mechanisms across them, and their relevance in choosing a synthetic membrane in Franz diffusion cell studies for formulation assessment purposes.

Original languageEnglish
Pages (from-to)579-593
Number of pages15
JournalArchives of Pharmacal Research
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 2012

Fingerprint

Drug Compounding
Membranes
Pharmaceutical Preparations
Quality Control
Quality control
Skin
Silicones
Macromolecules
Cellulose
Cornea
Esters

Keywords

  • Cellulose membranes
  • Formulation quality assessment
  • Franz diffusion cells
  • In vitro studies
  • Synthetic membranes

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Organic Chemistry

Cite this

The relevance of polymeric synthetic membranes in topical formulation assessment and drug diffusion study. / Ng, Shiow Fern; Rouse, Jennifer J.; Sanderson, Francis D.; Eccleston, Gillian M.

In: Archives of Pharmacal Research, Vol. 35, No. 4, 04.2012, p. 579-593.

Research output: Contribution to journalArticle

Ng, Shiow Fern ; Rouse, Jennifer J. ; Sanderson, Francis D. ; Eccleston, Gillian M. / The relevance of polymeric synthetic membranes in topical formulation assessment and drug diffusion study. In: Archives of Pharmacal Research. 2012 ; Vol. 35, No. 4. pp. 579-593.
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