The relationship between metabolic syndrome and osteoporosis: A Review

Sok Kuan Wong, Chin Kok Yong, Farihah Suhaimi, Fairus Ahmad, Ima Nirwana Soelaiman

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Metabolic syndrome (MetS) and osteoporosis are two major healthcare problems worldwide. Metabolic syndrome is a constellation of medical conditions consisting of central obesity, hyperglycemia, hypertension, and dyslipidemia, in which each acts on bone tissue in different ways. The growing prevalence of MetS and osteoporosis in the population along with the controversial findings on the relationship between both conditions suggest the importance for further investigation and discussion on this topic. This review aims to assess the available evidence on the effects of each component of MetS on bone metabolism from the conventional to the contemporary. Previous studies suggested that the two conditions shared some common underlying pathways, which include regulation of calcium homeostasis, receptor activator of NF-ĸB ligand (RANKL)/receptor activator of the NF-ĸB (RANK)/osteoprotegerin (OPG) and Wnt-β-catenin signaling pathways. In conclusion, we suggest that MetS may have a potential role in developing osteoporosis and more studies are necessary to further prove this hypothesis.

Original languageEnglish
Article number347
JournalNutrients
Volume8
Issue number6
DOIs
Publication statusPublished - 7 Jun 2016

Fingerprint

osteoporosis
metabolic syndrome
Osteoporosis
Calcium-Sensing Receptors
Osteoprotegerin
Bone and Bones
Catenins
bone metabolism
receptors
Wnt Signaling Pathway
Abdominal Obesity
hyperlipidemia
hyperglycemia
Dyslipidemias
Hyperglycemia
health services
hypertension
homeostasis
obesity
Homeostasis

Keywords

  • Bone
  • Dyslipidaemia
  • Hyperglycaemia
  • Hypertension
  • Obesity
  • Osteoporosis

ASJC Scopus subject areas

  • Food Science

Cite this

The relationship between metabolic syndrome and osteoporosis : A Review. / Wong, Sok Kuan; Kok Yong, Chin; Suhaimi, Farihah; Ahmad, Fairus; Soelaiman, Ima Nirwana.

In: Nutrients, Vol. 8, No. 6, 347, 07.06.2016.

Research output: Contribution to journalReview article

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