Abstract
Metabolic syndrome (MetS) and osteoporosis are two major healthcare problems worldwide. Metabolic syndrome is a constellation of medical conditions consisting of central obesity, hyperglycemia, hypertension, and dyslipidemia, in which each acts on bone tissue in different ways. The growing prevalence of MetS and osteoporosis in the population along with the controversial findings on the relationship between both conditions suggest the importance for further investigation and discussion on this topic. This review aims to assess the available evidence on the effects of each component of MetS on bone metabolism from the conventional to the contemporary. Previous studies suggested that the two conditions shared some common underlying pathways, which include regulation of calcium homeostasis, receptor activator of NF-ĸB ligand (RANKL)/receptor activator of the NF-ĸB (RANK)/osteoprotegerin (OPG) and Wnt-β-catenin signaling pathways. In conclusion, we suggest that MetS may have a potential role in developing osteoporosis and more studies are necessary to further prove this hypothesis.
| Original language | English |
|---|---|
| Article number | 347 |
| Journal | Nutrients |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 7 Jun 2016 |
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Keywords
- Bone
- Dyslipidaemia
- Hyperglycaemia
- Hypertension
- Obesity
- Osteoporosis
ASJC Scopus subject areas
- Food Science
Cite this
The relationship between metabolic syndrome and osteoporosis : A Review. / Wong, Sok Kuan; Kok Yong, Chin; Suhaimi, Farihah; Ahmad, Fairus; Soelaiman, Ima Nirwana.
In: Nutrients, Vol. 8, No. 6, 347, 07.06.2016.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - The relationship between metabolic syndrome and osteoporosis
T2 - A Review
AU - Wong, Sok Kuan
AU - Kok Yong, Chin
AU - Suhaimi, Farihah
AU - Ahmad, Fairus
AU - Soelaiman, Ima Nirwana
PY - 2016/6/7
Y1 - 2016/6/7
N2 - Metabolic syndrome (MetS) and osteoporosis are two major healthcare problems worldwide. Metabolic syndrome is a constellation of medical conditions consisting of central obesity, hyperglycemia, hypertension, and dyslipidemia, in which each acts on bone tissue in different ways. The growing prevalence of MetS and osteoporosis in the population along with the controversial findings on the relationship between both conditions suggest the importance for further investigation and discussion on this topic. This review aims to assess the available evidence on the effects of each component of MetS on bone metabolism from the conventional to the contemporary. Previous studies suggested that the two conditions shared some common underlying pathways, which include regulation of calcium homeostasis, receptor activator of NF-ĸB ligand (RANKL)/receptor activator of the NF-ĸB (RANK)/osteoprotegerin (OPG) and Wnt-β-catenin signaling pathways. In conclusion, we suggest that MetS may have a potential role in developing osteoporosis and more studies are necessary to further prove this hypothesis.
AB - Metabolic syndrome (MetS) and osteoporosis are two major healthcare problems worldwide. Metabolic syndrome is a constellation of medical conditions consisting of central obesity, hyperglycemia, hypertension, and dyslipidemia, in which each acts on bone tissue in different ways. The growing prevalence of MetS and osteoporosis in the population along with the controversial findings on the relationship between both conditions suggest the importance for further investigation and discussion on this topic. This review aims to assess the available evidence on the effects of each component of MetS on bone metabolism from the conventional to the contemporary. Previous studies suggested that the two conditions shared some common underlying pathways, which include regulation of calcium homeostasis, receptor activator of NF-ĸB ligand (RANKL)/receptor activator of the NF-ĸB (RANK)/osteoprotegerin (OPG) and Wnt-β-catenin signaling pathways. In conclusion, we suggest that MetS may have a potential role in developing osteoporosis and more studies are necessary to further prove this hypothesis.
KW - Bone
KW - Dyslipidaemia
KW - Hyperglycaemia
KW - Hypertension
KW - Obesity
KW - Osteoporosis
UR - http://www.scopus.com/inward/record.url?scp=84973345230&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973345230&partnerID=8YFLogxK
U2 - 10.3390/nu8060347
DO - 10.3390/nu8060347
M3 - Review article
C2 - 27338453
AN - SCOPUS:84973345230
VL - 8
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 6
M1 - 347
ER -