The Relationship between Long-term Use of Intranasal Corticosteroid and Intraocular Pressure

Ayesha Mohd Zain, Umi Kalthum Md Noh, Salina Hussein, Jemaima Che Hamzah, Safinaz Mohd Khialdin, Norshamsiah Md. Din

Research output: Contribution to journalArticle

Abstract

Purpose: The purpose of this study was to investigate the association between long-term intranasal steroid use and intraocular pressure (IOP) elevation. Patients and Methods: In total, 100 eyes from 50 patients on long-term intranasal steroids (>2 y) for allergic rhinitis and 90 eyes from 45 controls were included in this study. Patients on other forms of steroids and risk factors for glaucoma were excluded. IOP was measured and nonmydriatic stereoscopic optic disc photos were taken for each eye. The vertical cup-to-disc ratio and the status of the optic disc were evaluated. Results: The mean IOP for intranasal steroids group was significantly higher (15.24±2.31 mm Hg) compared to the control group (13.91±1.86 mm Hg; P=0.000). However, there were no significant differences in the vertical cup-to-disc ratio and the status of glaucomatous optic disc changes between the groups. Conclusions: Prolonged use of intranasal steroids cause statistical significant increase in IOP in patients with allergic rhinitis although no significant glaucomatous disc changes were seen. We suggest patients on long-term use of intranasal steroid have a yearly eye examination to be monitored for IOP elevation and those with additional risk factors for glaucoma is closely monitored for glaucoma.

Original languageEnglish
Pages (from-to)321-324
Number of pages4
JournalJournal of Glaucoma
Volume28
Issue number4
DOIs
Publication statusPublished - 1 Apr 2019

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Intraocular Pressure
Adrenal Cortex Hormones
Steroids
Optic Disk
Glaucoma
Control Groups

Keywords

  • glaucoma
  • intranasal corticosteroid
  • intraocular pressure

ASJC Scopus subject areas

  • Ophthalmology

Cite this

The Relationship between Long-term Use of Intranasal Corticosteroid and Intraocular Pressure. / Mohd Zain, Ayesha; Md Noh, Umi Kalthum; Hussein, Salina; Che Hamzah, Jemaima; Mohd Khialdin, Safinaz; Md. Din, Norshamsiah.

In: Journal of Glaucoma, Vol. 28, No. 4, 01.04.2019, p. 321-324.

Research output: Contribution to journalArticle

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