The prognostic value of C-reactive protein (CRP) levels in patients with acute ischaemic stroke

Bin Basri Hamidon, S. Sapiah, H. Nawawi, A. A. Raymond

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Increasing evidence suggests that inflammation plays an important role in the development of both cardiovascular and cerebrovascular events. Recently C-reactive protein (CRP) levels have been reported to be a prognostic factor for cerebrovascular and cardiovascular events. The main objective of the study was to evaluate the prognostic value of CRP levels in a first ever ischaemic stroke at one month. All ischaemic stroke patients who were admitted to Hospital Universiti Kebangsaan Malaysia (HUKM) between May 2002 and July 2002 were eligible for the study. CRP levels were taken within 72 hours after an acute ischaemic stroke. The functional ability was assessed using the Barthel Index (BI) after one month of stroke. During the study period 84 patients were admitted to HUKM with the diagnosis of ischaemic stroke; 49 patients were enrolled and 35 were excluded. Twenty-nine patients (59.2%) had elevated CRP levels (median 1.64 ± 3.07 mg/dL, range 0.06 to 16.21 mg/dL). Elevated CRP levels were found to be a predictor of severe functional disability (BI<5) and were also associated with larger infarcts. In conclusion, elevated CRP levels are associated with poorer functional outcome and predict a larger infarct size.

Original languageEnglish
Pages (from-to)631-637
Number of pages7
JournalMedical Journal of Malaysia
Volume59
Issue number5
Publication statusPublished - 2004

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C-Reactive Protein
Stroke
Malaysia
Inflammation

Keywords

  • Acute ischaemic stroke
  • C-reactive protein

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The prognostic value of C-reactive protein (CRP) levels in patients with acute ischaemic stroke. / Hamidon, Bin Basri; Sapiah, S.; Nawawi, H.; Raymond, A. A.

In: Medical Journal of Malaysia, Vol. 59, No. 5, 2004, p. 631-637.

Research output: Contribution to journalArticle

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