The presence of heterogeneous vancomycin-intermediate Staphylococcus aureus (heteroVISA) in a major Malaysian hospital

Norazah Ahmad, Law Ngiik Ling, Mohamed Kamel Abdul Ghani, Salbiah Nawi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This study was conducted to detect the presence of heterogenous vancomycin-intermediate Staphylococcus aureus (heteroVISA) among MRSA isolates in a major hospital. Forty-three MRSA isolates with vancomycin MIC 2 μg/ml collected in 2009 was screened for heteroVISA using Etest Glycopeptide Resistance Detection (GRD) and confirmed by population analysis profile-area under curve method. The genetic relatedness of heteroVISA strains with other MRSA was examined by pulsed-field gel electrophoresis (PFGE) method. Two isolates were shown to be heteroVISA and derived from the same clone. This showed that heteroVISA strains were already present among our local strains since 2009 and were genetically related to other susceptible strains.

Original languageEnglish
Pages (from-to)269-273
Number of pages5
JournalMedical Journal of Malaysia
Volume67
Issue number3
Publication statusPublished - Jun 2012

Fingerprint

Vancomycin
Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
Disk Diffusion Antimicrobial Tests
Glycopeptides
Pulsed Field Gel Electrophoresis
Area Under Curve
Clone Cells
Population

Keywords

  • Etest GRD
  • Heterovisa
  • MRSA
  • Population analysis
  • Pulsed-field gel electrophoresis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The presence of heterogeneous vancomycin-intermediate Staphylococcus aureus (heteroVISA) in a major Malaysian hospital. / Ahmad, Norazah; Ling, Law Ngiik; Abdul Ghani, Mohamed Kamel; Nawi, Salbiah.

In: Medical Journal of Malaysia, Vol. 67, No. 3, 06.2012, p. 269-273.

Research output: Contribution to journalArticle

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