The potential of canarium odontophyllum Miq. (dabai) as anti-methicillin resistant staphylococcus aureus agent

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Abstract

Objective: The present study evaluates the antimicrobial potential of C. Odontophyllum leaves against Methicillin-resistant Staphylococcus aureus, Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Aspergillus fumigatus, Aspergillus niger and Aspergillus flavus.

Materials: The extracts from C. odontophyllum leaf were prepared using acetone, methanol and distilled waterprior to screening at concentrations from12.5 mg/ml to 100 mg/ml against the test microorganisms using disc diffusion method. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts against susceptible organisms were determined using microbroth dilution method and streak-plate technique, respectively.

Results: Water produced the highest yield of extract (5.03%) followed by methanol (2.65%) and acetone (1.79%). Out of all the microbes tested, only MRSA was found to be susceptible towards acetone and methanol extracts of C. odontophyllum leaves which showed concentration-dependent growth inhibitory effect against MRSA. Despite the highest extractive potential of water, no antimicrobial activity was observed by the aqueous extract from the screening assay. The MIC values for methanol and acetone extracts were respectively,6.25 mg/ml and 3.125 mg/ml. The MBC value of methanol extract was twice its MIC value which was 12.5 mg/ml whereas the MIC and MBC values of acetone extract against MRSA were the same (3.125 mg/ml).

Conclusion: C. odontophyllum leaves have the potential to be developed as an alternative phytotherapeutic agent against MRSA infection.

Original languageEnglish
Pages (from-to)290-293
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume6
Issue number9
Publication statusPublished - 2014

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Methicillin-Resistant Staphylococcus aureus
Acetone
Methanol
Microbial Sensitivity Tests
Candida tropicalis
Candida glabrata
Aspergillus flavus
Aspergillus fumigatus
Aspergillus niger
Water
Candida albicans
Candida
Growth
Infection

Keywords

  • Antimicrobial
  • Canarium odontophyllum
  • Disc diffusion
  • MBC
  • MIC
  • MRSA

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

@article{aa96784ebd9b4bc2bf4b51357a2501c0,
title = "The potential of canarium odontophyllum Miq. (dabai) as anti-methicillin resistant staphylococcus aureus agent",
abstract = "Objective: The present study evaluates the antimicrobial potential of C. Odontophyllum leaves against Methicillin-resistant Staphylococcus aureus, Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Aspergillus fumigatus, Aspergillus niger and Aspergillus flavus.Materials: The extracts from C. odontophyllum leaf were prepared using acetone, methanol and distilled waterprior to screening at concentrations from12.5 mg/ml to 100 mg/ml against the test microorganisms using disc diffusion method. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts against susceptible organisms were determined using microbroth dilution method and streak-plate technique, respectively.Results: Water produced the highest yield of extract (5.03{\%}) followed by methanol (2.65{\%}) and acetone (1.79{\%}). Out of all the microbes tested, only MRSA was found to be susceptible towards acetone and methanol extracts of C. odontophyllum leaves which showed concentration-dependent growth inhibitory effect against MRSA. Despite the highest extractive potential of water, no antimicrobial activity was observed by the aqueous extract from the screening assay. The MIC values for methanol and acetone extracts were respectively,6.25 mg/ml and 3.125 mg/ml. The MBC value of methanol extract was twice its MIC value which was 12.5 mg/ml whereas the MIC and MBC values of acetone extract against MRSA were the same (3.125 mg/ml).Conclusion: C. odontophyllum leaves have the potential to be developed as an alternative phytotherapeutic agent against MRSA infection.",
keywords = "Antimicrobial, Canarium odontophyllum, Disc diffusion, MBC, MIC, MRSA",
author = "Basri, {Dayang Fredalina} and Zainal, {N. H.} and Jacinta Santhanam",
year = "2014",
language = "English",
volume = "6",
pages = "290--293",
journal = "International Journal of Pharmacy and Pharmaceutical Sciences",
issn = "0975-1491",
publisher = "IJPPS",
number = "9",

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TY - JOUR

T1 - The potential of canarium odontophyllum Miq. (dabai) as anti-methicillin resistant staphylococcus aureus agent

AU - Basri, Dayang Fredalina

AU - Zainal, N. H.

AU - Santhanam, Jacinta

PY - 2014

Y1 - 2014

N2 - Objective: The present study evaluates the antimicrobial potential of C. Odontophyllum leaves against Methicillin-resistant Staphylococcus aureus, Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Aspergillus fumigatus, Aspergillus niger and Aspergillus flavus.Materials: The extracts from C. odontophyllum leaf were prepared using acetone, methanol and distilled waterprior to screening at concentrations from12.5 mg/ml to 100 mg/ml against the test microorganisms using disc diffusion method. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts against susceptible organisms were determined using microbroth dilution method and streak-plate technique, respectively.Results: Water produced the highest yield of extract (5.03%) followed by methanol (2.65%) and acetone (1.79%). Out of all the microbes tested, only MRSA was found to be susceptible towards acetone and methanol extracts of C. odontophyllum leaves which showed concentration-dependent growth inhibitory effect against MRSA. Despite the highest extractive potential of water, no antimicrobial activity was observed by the aqueous extract from the screening assay. The MIC values for methanol and acetone extracts were respectively,6.25 mg/ml and 3.125 mg/ml. The MBC value of methanol extract was twice its MIC value which was 12.5 mg/ml whereas the MIC and MBC values of acetone extract against MRSA were the same (3.125 mg/ml).Conclusion: C. odontophyllum leaves have the potential to be developed as an alternative phytotherapeutic agent against MRSA infection.

AB - Objective: The present study evaluates the antimicrobial potential of C. Odontophyllum leaves against Methicillin-resistant Staphylococcus aureus, Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Aspergillus fumigatus, Aspergillus niger and Aspergillus flavus.Materials: The extracts from C. odontophyllum leaf were prepared using acetone, methanol and distilled waterprior to screening at concentrations from12.5 mg/ml to 100 mg/ml against the test microorganisms using disc diffusion method. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the extracts against susceptible organisms were determined using microbroth dilution method and streak-plate technique, respectively.Results: Water produced the highest yield of extract (5.03%) followed by methanol (2.65%) and acetone (1.79%). Out of all the microbes tested, only MRSA was found to be susceptible towards acetone and methanol extracts of C. odontophyllum leaves which showed concentration-dependent growth inhibitory effect against MRSA. Despite the highest extractive potential of water, no antimicrobial activity was observed by the aqueous extract from the screening assay. The MIC values for methanol and acetone extracts were respectively,6.25 mg/ml and 3.125 mg/ml. The MBC value of methanol extract was twice its MIC value which was 12.5 mg/ml whereas the MIC and MBC values of acetone extract against MRSA were the same (3.125 mg/ml).Conclusion: C. odontophyllum leaves have the potential to be developed as an alternative phytotherapeutic agent against MRSA infection.

KW - Antimicrobial

KW - Canarium odontophyllum

KW - Disc diffusion

KW - MBC

KW - MIC

KW - MRSA

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