The osteoprotective effects of Kaempferol: The evidence from in vivo and in vitro studies

Research output: Contribution to journalReview article

Abstract

Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many reports have acknowledged the bone-protecting property of kaempferol and kaempferol-containing plants using in vitro and in vivo experimental models. Kaempferol supplementa-tion showed bone-sparing effects in newborn rats, glucocorticoid-induced and ovariectomy-induced osteoporotic models as well as bone fracture models. It achieves the bone-protective effects by inhibiting adipogenesis, inflammation, oxidative stress, osteoclastic autophagy and osteoblastic apoptosis while activating osteoblastic autophagy. The anti-osteoporotic effects of kaempferol are mediated through regulation of estrogen receptor, bone morphogenetic protein-2 (BMP-2), nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways. In summary, kaempferol exhibits beneficial effects on skeleton, thus is potentially effective for the prophylaxis and treatment of osteoporosis.

Original languageEnglish
Pages (from-to)3497-3514
Number of pages18
JournalDrug Design, Development and Therapy
Volume13
DOIs
Publication statusPublished - 1 Jan 2019

Fingerprint

Bone and Bones
Autophagy
Adipogenesis
Bone Morphogenetic Protein 2
Osteoporotic Fractures
NF-kappa B
Bone Fractures
Ovariectomy
Sirolimus
In Vitro Techniques
kaempferol
Mitogen-Activated Protein Kinases
Flavonoids
Skeleton
Estrogen Receptors
Glucocorticoids
Osteoporosis
Oxidative Stress
Theoretical Models
Apoptosis

Keywords

  • Bone
  • Flavonoid
  • Fracture
  • Osteoblast
  • Osteoclast
  • Osteoporosis

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

The osteoprotective effects of Kaempferol : The evidence from in vivo and in vitro studies. / Wong, Sok Kuan; Chin, Kok Yong; Ima-Nirwana, Soelaiman.

In: Drug Design, Development and Therapy, Vol. 13, 01.01.2019, p. 3497-3514.

Research output: Contribution to journalReview article

@article{16812224ca1b43028e5302ad070ba907,
title = "The osteoprotective effects of Kaempferol: The evidence from in vivo and in vitro studies",
abstract = "Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many reports have acknowledged the bone-protecting property of kaempferol and kaempferol-containing plants using in vitro and in vivo experimental models. Kaempferol supplementa-tion showed bone-sparing effects in newborn rats, glucocorticoid-induced and ovariectomy-induced osteoporotic models as well as bone fracture models. It achieves the bone-protective effects by inhibiting adipogenesis, inflammation, oxidative stress, osteoclastic autophagy and osteoblastic apoptosis while activating osteoblastic autophagy. The anti-osteoporotic effects of kaempferol are mediated through regulation of estrogen receptor, bone morphogenetic protein-2 (BMP-2), nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways. In summary, kaempferol exhibits beneficial effects on skeleton, thus is potentially effective for the prophylaxis and treatment of osteoporosis.",
keywords = "Bone, Flavonoid, Fracture, Osteoblast, Osteoclast, Osteoporosis",
author = "Wong, {Sok Kuan} and Chin, {Kok Yong} and Soelaiman Ima-Nirwana",
year = "2019",
month = "1",
day = "1",
doi = "10.2147/DDDT.S227738",
language = "English",
volume = "13",
pages = "3497--3514",
journal = "Drug Design, Development and Therapy",
issn = "1177-8881",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - The osteoprotective effects of Kaempferol

T2 - The evidence from in vivo and in vitro studies

AU - Wong, Sok Kuan

AU - Chin, Kok Yong

AU - Ima-Nirwana, Soelaiman

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many reports have acknowledged the bone-protecting property of kaempferol and kaempferol-containing plants using in vitro and in vivo experimental models. Kaempferol supplementa-tion showed bone-sparing effects in newborn rats, glucocorticoid-induced and ovariectomy-induced osteoporotic models as well as bone fracture models. It achieves the bone-protective effects by inhibiting adipogenesis, inflammation, oxidative stress, osteoclastic autophagy and osteoblastic apoptosis while activating osteoblastic autophagy. The anti-osteoporotic effects of kaempferol are mediated through regulation of estrogen receptor, bone morphogenetic protein-2 (BMP-2), nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways. In summary, kaempferol exhibits beneficial effects on skeleton, thus is potentially effective for the prophylaxis and treatment of osteoporosis.

AB - Kaempferol is a dietary bioflavonoid ubiquitously found in various types of plant. It possesses a wide range of medicinal properties suggesting its potential clinical utility that requires further investigation. The present review intends to highlight the efficacy of kaempferol and its molecular mechanisms of action in regulating bone metabolism. Many reports have acknowledged the bone-protecting property of kaempferol and kaempferol-containing plants using in vitro and in vivo experimental models. Kaempferol supplementa-tion showed bone-sparing effects in newborn rats, glucocorticoid-induced and ovariectomy-induced osteoporotic models as well as bone fracture models. It achieves the bone-protective effects by inhibiting adipogenesis, inflammation, oxidative stress, osteoclastic autophagy and osteoblastic apoptosis while activating osteoblastic autophagy. The anti-osteoporotic effects of kaempferol are mediated through regulation of estrogen receptor, bone morphogenetic protein-2 (BMP-2), nuclear factor-kappa B (NF-κB), mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) signaling pathways. In summary, kaempferol exhibits beneficial effects on skeleton, thus is potentially effective for the prophylaxis and treatment of osteoporosis.

KW - Bone

KW - Flavonoid

KW - Fracture

KW - Osteoblast

KW - Osteoclast

KW - Osteoporosis

UR - http://www.scopus.com/inward/record.url?scp=85073424599&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073424599&partnerID=8YFLogxK

U2 - 10.2147/DDDT.S227738

DO - 10.2147/DDDT.S227738

M3 - Review article

C2 - 31631974

AN - SCOPUS:85073424599

VL - 13

SP - 3497

EP - 3514

JO - Drug Design, Development and Therapy

JF - Drug Design, Development and Therapy

SN - 1177-8881

ER -