The mammalian auditory hair cell: A simple electric circuit it model

F. Rattay, I. C. Gebeshuber, A. H. Gitter

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

A model based on the potassium current pathway through the hair cell is used to analyze the electrical behavior of mammalian inner and outer hair cells. Without taking into account the effects of calcium it is possible to simulate experimental results concerning the shape and strength of the receptor potential and the frequency dependent ac (alternating current) and dc (direct current) components of the receptor current. This model and a simplified form of it are utilized to explain: (1) Transduction latencies: that the receptor potential follows a stimulating signal with a very short delay, under the assumption of a constant number of open K+ channels in the lateral part of the cell membrane. (2) Transduction gains: why higher potential changes are measured in inner hair cells than in outer hair cells, although the outer hair cells are expected to be exposed to higher stereociliary motions: in inner hair cells a decrease in the conductance of the basolateral membrane causes higher gain (receptor potential increases) and together with an increase of membrane capacitance slower reaction (a larger time constant). (3) Transduction channel kinetics: that the shortest (0.1 ms) as well as the longest (20 ms) possible open times of the transduction channels in the stereocilia have different frequency related effects on the shape of the receptor potentials.

Original languageEnglish
Pages (from-to)1558-1565
Number of pages8
JournalJournal of the Acoustical Society of America
Volume103
Issue number3
DOIs
Publication statusPublished - Mar 1998
Externally publishedYes

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hair
high gain
membranes
time constant
Hearing
Cells
calcium
potassium
alternating current
capacitance
direct current
causes
kinetics
Transduction
Membrane

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

Cite this

The mammalian auditory hair cell : A simple electric circuit it model. / Rattay, F.; Gebeshuber, I. C.; Gitter, A. H.

In: Journal of the Acoustical Society of America, Vol. 103, No. 3, 03.1998, p. 1558-1565.

Research output: Contribution to journalArticle

Rattay, F. ; Gebeshuber, I. C. ; Gitter, A. H. / The mammalian auditory hair cell : A simple electric circuit it model. In: Journal of the Acoustical Society of America. 1998 ; Vol. 103, No. 3. pp. 1558-1565.
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