The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction: A cardiovascular magnetic resonance study

Masliza Mahmod, Nikhil Pal, Jennifer Rayner, Cameron Holloway, Betty Raman, Sairia Dass, Eylem Levelt, Rina Ariga, Vanessa Ferreira, Rajarshi Banerjee, Jurgen E. Schneider, Christopher Rodgers, Jane M. Francis, Theodoros D. Karamitsos, Michael Frenneaux, Houman Ashrafian, Stefan Neubauer, Oliver Rider

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Heart failure (HF) is characterized by altered myocardial substrate metabolism which can lead to myocardial triglyceride accumulation (steatosis) and lipotoxicity. However its role in mild HF with preserved ejection fraction (HFpEF) is uncertain. We measured myocardial triglyceride content (MTG) in HFpEF and assessed its relationships with diastolic function and exercise capacity. Methods: Twenty seven HFpEF (clinical features of HF, left ventricular EF >50%, evidence of mild diastolic dysfunction and evidence of exercise limitation as assessed by cardiopulmonary exercise test) and 14 controls underwent 1H-cardiovascular magnetic resonance spectroscopy (1H-CMRS) to measure MTG (lipid/water, %), 31P-CMRS to measure myocardial energetics (phosphocreatine-to-adenosine triphosphate - PCr/ATP) and feature-tracking cardiovascular magnetic resonance (CMR) imaging for diastolic strain rate. Results: When compared to controls, HFpEF had 2.3 fold higher in MTG (1.45 ± 0.25% vs. 0.64 ± 0.16%, p = 0.009) and reduced PCr/ATP (1.60 ± 0.09 vs. 2.00 ± 0.10, p = 0.005). HFpEF had significantly reduced diastolic strain rate and maximal oxygen consumption (VO2 max), which both correlated significantly with elevated MTG and reduced PCr/ATP. On multivariate analyses, MTG was independently associated with diastolic strain rate while diastolic strain rate was independently associated with VO2 max. Conclusions: Myocardial steatosis is pronounced in mild HFpEF, and is independently associated with impaired diastolic strain rate which is itself related to exercise capacity. Steatosis may adversely affect exercise capacity by indirect effect occurring via impairment in diastolic function. As such, myocardial triglyceride may become a potential therapeutic target to treat the increasing number of patients with HFpEF.

Original languageEnglish
Article number88
JournalJournal of Cardiovascular Magnetic Resonance
Volume20
Issue number1
DOIs
Publication statusPublished - 24 Dec 2018

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Triglycerides
Magnetic Resonance Spectroscopy
Heart Failure
Adenosine Triphosphate
Exercise
Phosphocreatine
Exercise Test
Oxygen Consumption
Multivariate Analysis
Magnetic Resonance Imaging
Lipids
Water

Keywords

  • Cardiovascular magnetic resonance
  • Diastolic strain rate
  • Heart failure
  • Maximal oxygen consumption
  • Spectroscopy
  • Steatosis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction : A cardiovascular magnetic resonance study. / Mahmod, Masliza; Pal, Nikhil; Rayner, Jennifer; Holloway, Cameron; Raman, Betty; Dass, Sairia; Levelt, Eylem; Ariga, Rina; Ferreira, Vanessa; Banerjee, Rajarshi; Schneider, Jurgen E.; Rodgers, Christopher; Francis, Jane M.; Karamitsos, Theodoros D.; Frenneaux, Michael; Ashrafian, Houman; Neubauer, Stefan; Rider, Oliver.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 20, No. 1, 88, 24.12.2018.

Research output: Contribution to journalArticle

Mahmod, M, Pal, N, Rayner, J, Holloway, C, Raman, B, Dass, S, Levelt, E, Ariga, R, Ferreira, V, Banerjee, R, Schneider, JE, Rodgers, C, Francis, JM, Karamitsos, TD, Frenneaux, M, Ashrafian, H, Neubauer, S & Rider, O 2018, 'The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction: A cardiovascular magnetic resonance study', Journal of Cardiovascular Magnetic Resonance, vol. 20, no. 1, 88. https://doi.org/10.1186/s12968-018-0511-6
Mahmod, Masliza ; Pal, Nikhil ; Rayner, Jennifer ; Holloway, Cameron ; Raman, Betty ; Dass, Sairia ; Levelt, Eylem ; Ariga, Rina ; Ferreira, Vanessa ; Banerjee, Rajarshi ; Schneider, Jurgen E. ; Rodgers, Christopher ; Francis, Jane M. ; Karamitsos, Theodoros D. ; Frenneaux, Michael ; Ashrafian, Houman ; Neubauer, Stefan ; Rider, Oliver. / The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction : A cardiovascular magnetic resonance study. In: Journal of Cardiovascular Magnetic Resonance. 2018 ; Vol. 20, No. 1.
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abstract = "Background: Heart failure (HF) is characterized by altered myocardial substrate metabolism which can lead to myocardial triglyceride accumulation (steatosis) and lipotoxicity. However its role in mild HF with preserved ejection fraction (HFpEF) is uncertain. We measured myocardial triglyceride content (MTG) in HFpEF and assessed its relationships with diastolic function and exercise capacity. Methods: Twenty seven HFpEF (clinical features of HF, left ventricular EF >50{\%}, evidence of mild diastolic dysfunction and evidence of exercise limitation as assessed by cardiopulmonary exercise test) and 14 controls underwent 1H-cardiovascular magnetic resonance spectroscopy (1H-CMRS) to measure MTG (lipid/water, {\%}), 31P-CMRS to measure myocardial energetics (phosphocreatine-to-adenosine triphosphate - PCr/ATP) and feature-tracking cardiovascular magnetic resonance (CMR) imaging for diastolic strain rate. Results: When compared to controls, HFpEF had 2.3 fold higher in MTG (1.45 ± 0.25{\%} vs. 0.64 ± 0.16{\%}, p = 0.009) and reduced PCr/ATP (1.60 ± 0.09 vs. 2.00 ± 0.10, p = 0.005). HFpEF had significantly reduced diastolic strain rate and maximal oxygen consumption (VO2 max), which both correlated significantly with elevated MTG and reduced PCr/ATP. On multivariate analyses, MTG was independently associated with diastolic strain rate while diastolic strain rate was independently associated with VO2 max. Conclusions: Myocardial steatosis is pronounced in mild HFpEF, and is independently associated with impaired diastolic strain rate which is itself related to exercise capacity. Steatosis may adversely affect exercise capacity by indirect effect occurring via impairment in diastolic function. As such, myocardial triglyceride may become a potential therapeutic target to treat the increasing number of patients with HFpEF.",
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T1 - The interplay between metabolic alterations, diastolic strain rate and exercise capacity in mild heart failure with preserved ejection fraction

T2 - A cardiovascular magnetic resonance study

AU - Mahmod, Masliza

AU - Pal, Nikhil

AU - Rayner, Jennifer

AU - Holloway, Cameron

AU - Raman, Betty

AU - Dass, Sairia

AU - Levelt, Eylem

AU - Ariga, Rina

AU - Ferreira, Vanessa

AU - Banerjee, Rajarshi

AU - Schneider, Jurgen E.

AU - Rodgers, Christopher

AU - Francis, Jane M.

AU - Karamitsos, Theodoros D.

AU - Frenneaux, Michael

AU - Ashrafian, Houman

AU - Neubauer, Stefan

AU - Rider, Oliver

PY - 2018/12/24

Y1 - 2018/12/24

N2 - Background: Heart failure (HF) is characterized by altered myocardial substrate metabolism which can lead to myocardial triglyceride accumulation (steatosis) and lipotoxicity. However its role in mild HF with preserved ejection fraction (HFpEF) is uncertain. We measured myocardial triglyceride content (MTG) in HFpEF and assessed its relationships with diastolic function and exercise capacity. Methods: Twenty seven HFpEF (clinical features of HF, left ventricular EF >50%, evidence of mild diastolic dysfunction and evidence of exercise limitation as assessed by cardiopulmonary exercise test) and 14 controls underwent 1H-cardiovascular magnetic resonance spectroscopy (1H-CMRS) to measure MTG (lipid/water, %), 31P-CMRS to measure myocardial energetics (phosphocreatine-to-adenosine triphosphate - PCr/ATP) and feature-tracking cardiovascular magnetic resonance (CMR) imaging for diastolic strain rate. Results: When compared to controls, HFpEF had 2.3 fold higher in MTG (1.45 ± 0.25% vs. 0.64 ± 0.16%, p = 0.009) and reduced PCr/ATP (1.60 ± 0.09 vs. 2.00 ± 0.10, p = 0.005). HFpEF had significantly reduced diastolic strain rate and maximal oxygen consumption (VO2 max), which both correlated significantly with elevated MTG and reduced PCr/ATP. On multivariate analyses, MTG was independently associated with diastolic strain rate while diastolic strain rate was independently associated with VO2 max. Conclusions: Myocardial steatosis is pronounced in mild HFpEF, and is independently associated with impaired diastolic strain rate which is itself related to exercise capacity. Steatosis may adversely affect exercise capacity by indirect effect occurring via impairment in diastolic function. As such, myocardial triglyceride may become a potential therapeutic target to treat the increasing number of patients with HFpEF.

AB - Background: Heart failure (HF) is characterized by altered myocardial substrate metabolism which can lead to myocardial triglyceride accumulation (steatosis) and lipotoxicity. However its role in mild HF with preserved ejection fraction (HFpEF) is uncertain. We measured myocardial triglyceride content (MTG) in HFpEF and assessed its relationships with diastolic function and exercise capacity. Methods: Twenty seven HFpEF (clinical features of HF, left ventricular EF >50%, evidence of mild diastolic dysfunction and evidence of exercise limitation as assessed by cardiopulmonary exercise test) and 14 controls underwent 1H-cardiovascular magnetic resonance spectroscopy (1H-CMRS) to measure MTG (lipid/water, %), 31P-CMRS to measure myocardial energetics (phosphocreatine-to-adenosine triphosphate - PCr/ATP) and feature-tracking cardiovascular magnetic resonance (CMR) imaging for diastolic strain rate. Results: When compared to controls, HFpEF had 2.3 fold higher in MTG (1.45 ± 0.25% vs. 0.64 ± 0.16%, p = 0.009) and reduced PCr/ATP (1.60 ± 0.09 vs. 2.00 ± 0.10, p = 0.005). HFpEF had significantly reduced diastolic strain rate and maximal oxygen consumption (VO2 max), which both correlated significantly with elevated MTG and reduced PCr/ATP. On multivariate analyses, MTG was independently associated with diastolic strain rate while diastolic strain rate was independently associated with VO2 max. Conclusions: Myocardial steatosis is pronounced in mild HFpEF, and is independently associated with impaired diastolic strain rate which is itself related to exercise capacity. Steatosis may adversely affect exercise capacity by indirect effect occurring via impairment in diastolic function. As such, myocardial triglyceride may become a potential therapeutic target to treat the increasing number of patients with HFpEF.

KW - Cardiovascular magnetic resonance

KW - Diastolic strain rate

KW - Heart failure

KW - Maximal oxygen consumption

KW - Spectroscopy

KW - Steatosis

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