The influence of selenium status on body composition, oxidative DNA damage and total antioxidant capacity in newly diagnosed type 2 diabetes mellitus: A case-control study

Fatimah binti Othman, Hamid Jan bin Jan Mohamed, K. N S Sirajudeen, Mohd Fairulnizal b Md Noh, Nor Fadilah Rajab

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Selenium is involved in the complex system of defense against oxidative stress in diabetes through its biological function of selenoproteins and the antioxidant enzyme. A case-control study was carried out to determine the association of plasma selenium with oxidative stress and body composition status presented in Type 2 Diabetes Mellitus (T2DM) patient and healthy control. This study involved 82 newly diagnosed T2DM patients and 82 healthy controls. Plasma selenium status was determined with Graphite Furnace Atomic Absorption Spectrometry. Body Mass Index, total body fat and visceral fat was assessed for body composition using Body Composition Analyzer (TANITA). Oxidative DNA damage and total antioxidant capacity were determined for oxidative stress biomarker status. In age, gender and BMI adjustment, no significant difference of plasma selenium level between T2DM and healthy controls was observed. There was as a significant difference of Oxidative DNA damage and total antioxidant capacity between T2DM patients and healthy controls with tail DNA% 20.62 [95% CI: 19.71,21.49] (T2DM), 17.67 [95% CI: 16.87,18.56] (control); log tail moment 0.41[95% CI: 0.30,0.52] (T2DM), 0.41[95% CI: 0.30,0.52] (control); total antioxidant capacity 0.56 [95% CI: 0.54,0.58] (T2DM), 0.60 [95% CI: 0.57,0.62] (control). Waist circumference, BMI, visceral fat, body fat and oxidative DNA damage in the T2DM group were significantly lower in the first plasma selenium tertile (38.65-80.90. μg/L) compared to the second (80.91-98.20. μg/L) and the third selenium tertiles (98.21-158.20. μg/L). A similar trend, but not statistically significant, was observed in the control group.

Original languageEnglish
JournalJournal of Trace Elements in Medicine and Biology
DOIs
Publication statusAccepted/In press - 24 Aug 2016

Fingerprint

Medical problems
Selenium
Body Composition
Type 2 Diabetes Mellitus
DNA Damage
Case-Control Studies
Antioxidants
DNA
Chemical analysis
Oxidative stress
Fats
Oxidative Stress
Plasmas
Intra-Abdominal Fat
Adipose Tissue
Selenoproteins
Fat Body
Graphite
Atomic absorption spectrometry
Waist Circumference

Keywords

  • Body composition
  • Graphite Furnace Atomic Absorption Spectrometry
  • Oxidative DNA damage
  • Selenium
  • Total antioxidant capacity
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Inorganic Chemistry

Cite this

The influence of selenium status on body composition, oxidative DNA damage and total antioxidant capacity in newly diagnosed type 2 diabetes mellitus : A case-control study. / Othman, Fatimah binti; Mohamed, Hamid Jan bin Jan; Sirajudeen, K. N S; Noh, Mohd Fairulnizal b Md; Rajab, Nor Fadilah.

In: Journal of Trace Elements in Medicine and Biology, 24.08.2016.

Research output: Contribution to journalArticle

@article{429e46aca79d4d51a0acc01b1318ec40,
title = "The influence of selenium status on body composition, oxidative DNA damage and total antioxidant capacity in newly diagnosed type 2 diabetes mellitus: A case-control study",
abstract = "Selenium is involved in the complex system of defense against oxidative stress in diabetes through its biological function of selenoproteins and the antioxidant enzyme. A case-control study was carried out to determine the association of plasma selenium with oxidative stress and body composition status presented in Type 2 Diabetes Mellitus (T2DM) patient and healthy control. This study involved 82 newly diagnosed T2DM patients and 82 healthy controls. Plasma selenium status was determined with Graphite Furnace Atomic Absorption Spectrometry. Body Mass Index, total body fat and visceral fat was assessed for body composition using Body Composition Analyzer (TANITA). Oxidative DNA damage and total antioxidant capacity were determined for oxidative stress biomarker status. In age, gender and BMI adjustment, no significant difference of plasma selenium level between T2DM and healthy controls was observed. There was as a significant difference of Oxidative DNA damage and total antioxidant capacity between T2DM patients and healthy controls with tail DNA{\%} 20.62 [95{\%} CI: 19.71,21.49] (T2DM), 17.67 [95{\%} CI: 16.87,18.56] (control); log tail moment 0.41[95{\%} CI: 0.30,0.52] (T2DM), 0.41[95{\%} CI: 0.30,0.52] (control); total antioxidant capacity 0.56 [95{\%} CI: 0.54,0.58] (T2DM), 0.60 [95{\%} CI: 0.57,0.62] (control). Waist circumference, BMI, visceral fat, body fat and oxidative DNA damage in the T2DM group were significantly lower in the first plasma selenium tertile (38.65-80.90. μg/L) compared to the second (80.91-98.20. μg/L) and the third selenium tertiles (98.21-158.20. μg/L). A similar trend, but not statistically significant, was observed in the control group.",
keywords = "Body composition, Graphite Furnace Atomic Absorption Spectrometry, Oxidative DNA damage, Selenium, Total antioxidant capacity, Type 2 diabetes mellitus",
author = "Othman, {Fatimah binti} and Mohamed, {Hamid Jan bin Jan} and Sirajudeen, {K. N S} and Noh, {Mohd Fairulnizal b Md} and Rajab, {Nor Fadilah}",
year = "2016",
month = "8",
day = "24",
doi = "10.1016/j.jtemb.2016.12.009",
language = "English",
journal = "Journal of Trace Elements in Medicine and Biology",
issn = "0946-672X",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",

}

TY - JOUR

T1 - The influence of selenium status on body composition, oxidative DNA damage and total antioxidant capacity in newly diagnosed type 2 diabetes mellitus

T2 - A case-control study

AU - Othman, Fatimah binti

AU - Mohamed, Hamid Jan bin Jan

AU - Sirajudeen, K. N S

AU - Noh, Mohd Fairulnizal b Md

AU - Rajab, Nor Fadilah

PY - 2016/8/24

Y1 - 2016/8/24

N2 - Selenium is involved in the complex system of defense against oxidative stress in diabetes through its biological function of selenoproteins and the antioxidant enzyme. A case-control study was carried out to determine the association of plasma selenium with oxidative stress and body composition status presented in Type 2 Diabetes Mellitus (T2DM) patient and healthy control. This study involved 82 newly diagnosed T2DM patients and 82 healthy controls. Plasma selenium status was determined with Graphite Furnace Atomic Absorption Spectrometry. Body Mass Index, total body fat and visceral fat was assessed for body composition using Body Composition Analyzer (TANITA). Oxidative DNA damage and total antioxidant capacity were determined for oxidative stress biomarker status. In age, gender and BMI adjustment, no significant difference of plasma selenium level between T2DM and healthy controls was observed. There was as a significant difference of Oxidative DNA damage and total antioxidant capacity between T2DM patients and healthy controls with tail DNA% 20.62 [95% CI: 19.71,21.49] (T2DM), 17.67 [95% CI: 16.87,18.56] (control); log tail moment 0.41[95% CI: 0.30,0.52] (T2DM), 0.41[95% CI: 0.30,0.52] (control); total antioxidant capacity 0.56 [95% CI: 0.54,0.58] (T2DM), 0.60 [95% CI: 0.57,0.62] (control). Waist circumference, BMI, visceral fat, body fat and oxidative DNA damage in the T2DM group were significantly lower in the first plasma selenium tertile (38.65-80.90. μg/L) compared to the second (80.91-98.20. μg/L) and the third selenium tertiles (98.21-158.20. μg/L). A similar trend, but not statistically significant, was observed in the control group.

AB - Selenium is involved in the complex system of defense against oxidative stress in diabetes through its biological function of selenoproteins and the antioxidant enzyme. A case-control study was carried out to determine the association of plasma selenium with oxidative stress and body composition status presented in Type 2 Diabetes Mellitus (T2DM) patient and healthy control. This study involved 82 newly diagnosed T2DM patients and 82 healthy controls. Plasma selenium status was determined with Graphite Furnace Atomic Absorption Spectrometry. Body Mass Index, total body fat and visceral fat was assessed for body composition using Body Composition Analyzer (TANITA). Oxidative DNA damage and total antioxidant capacity were determined for oxidative stress biomarker status. In age, gender and BMI adjustment, no significant difference of plasma selenium level between T2DM and healthy controls was observed. There was as a significant difference of Oxidative DNA damage and total antioxidant capacity between T2DM patients and healthy controls with tail DNA% 20.62 [95% CI: 19.71,21.49] (T2DM), 17.67 [95% CI: 16.87,18.56] (control); log tail moment 0.41[95% CI: 0.30,0.52] (T2DM), 0.41[95% CI: 0.30,0.52] (control); total antioxidant capacity 0.56 [95% CI: 0.54,0.58] (T2DM), 0.60 [95% CI: 0.57,0.62] (control). Waist circumference, BMI, visceral fat, body fat and oxidative DNA damage in the T2DM group were significantly lower in the first plasma selenium tertile (38.65-80.90. μg/L) compared to the second (80.91-98.20. μg/L) and the third selenium tertiles (98.21-158.20. μg/L). A similar trend, but not statistically significant, was observed in the control group.

KW - Body composition

KW - Graphite Furnace Atomic Absorption Spectrometry

KW - Oxidative DNA damage

KW - Selenium

KW - Total antioxidant capacity

KW - Type 2 diabetes mellitus

UR - http://www.scopus.com/inward/record.url?scp=85008474503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85008474503&partnerID=8YFLogxK

U2 - 10.1016/j.jtemb.2016.12.009

DO - 10.1016/j.jtemb.2016.12.009

M3 - Article

C2 - 28065595

AN - SCOPUS:85008474503

JO - Journal of Trace Elements in Medicine and Biology

JF - Journal of Trace Elements in Medicine and Biology

SN - 0946-672X

ER -