The influence of fasting insulin level in post-gestational diabetes mellitus women receiving low-glycaemic-index diets

R. A. Ghani, S. Shyam, F. Arshad, Norasyikin A. Wahab @ A. Rahman, K. Chinna, Nik Shanita Safii, M. Y B Nisak, Nor Azmi Kamaruddin

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Abstract

Post-gestational diabetes mellitus (GDM) women are recommended weight loss to manage increased cardio-metabolic risks. We investigated the effects of lowering diet glycaemic index (GI) on fasting blood glucose (FBG), serum lipids, body weight and composition of post-GDM women with varying fasting insulin levels (INS). Seventy-seven Asian, non-diabetic women with previous GDM (aged 20-40 years, mean BMI: 26.4±4.6 kgm<sup>-2</sup>) were recruited. At baseline, 20 subjects with INS <2 μIU ml<sup>-1</sup> and 18 with INS ≥2 μIU ml<sup>-1</sup> received conventional dietary recommendations (CHDR) only. CHDR emphasised energy and fat intake restriction and encouraged increase in dietary fibre intakes. Twenty-four subjects with INS <2 μIU ml<sup>-1</sup> and 15 with INS ≥2 μIU ml<sup>-1</sup>, in addition to CHDR, received low-GI education (LGI). Changes in FBG, serum lipids, body weight and body composition were evaluated. Subjects with INS <2 μIU ml<sup>-1</sup> had similar outcomes with both diets. After 1 year, subjects with INS ≥2 μIU ml<sup>-1</sup> who received LGI education had reductions in FBG and triglycerides. Subjects who received CHDR observed increase in both FBG and triglycerides (P<0.05). Among all subjects, diet GI was lower and dietary fibre intakes were higher in LGI compared with CHDR subjects (all P<0.05). Thus, in Asian post-GDM women with normal/higher INS, adding low-GI education to CHDR improved management of FBG and triglycerides.

Original languageEnglish
Article numbere107
JournalNutrition and Diabetes
Volume4
Issue number2
DOIs
Publication statusPublished - 1 Jan 2014

Fingerprint

Glycemic Index
Gestational Diabetes
Fasting
Insulin
Diet
Blood Glucose
Education
Triglycerides
Dietary Fiber
Body Composition
Body Weight
Energy Intake
Serum
Weight Loss
Fats

Keywords

  • Diet
  • Fasting insulin
  • Gestational diabetes mellitus
  • Glycaemic index
  • Prevention
  • Type 2 diabetes mellitus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

The influence of fasting insulin level in post-gestational diabetes mellitus women receiving low-glycaemic-index diets. / Ghani, R. A.; Shyam, S.; Arshad, F.; A. Wahab @ A. Rahman, Norasyikin; Chinna, K.; Safii, Nik Shanita; Nisak, M. Y B; Kamaruddin, Nor Azmi.

In: Nutrition and Diabetes, Vol. 4, No. 2, e107, 01.01.2014.

Research output: Contribution to journalArticle

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