The incidence of thyroid gland invasion in patients with carcinoma of the larynx who underwent total laryngectomy

Azman Mawaddah, S. See-Sze, Marina Mat Baki, K. C. Pua, Abdullah Sani Mohamed

Research output: Contribution to journalArticle

Abstract

Introduction: Total thyroidectomy or at least hemithyroidectomy is routinely performed alongside total laryngectomy in patients with advanced carcinoma of the larynx. Life-threatening hypocalcaemia and hypothyroidism are common sequelae especially with adjuvant radiation. The study aims to determine the incidence of microscopic thyroid gland invasion and challenge the idea of routine thyroidectomy in advanced carcinoma of the larynx. Materials and Methods: This study was a retrospective observational study. It was done in two tertiary centres in Malaysia between 2003 and 2013 for a total duration of 11 years. A total of 72 patients were included in this study. Data from medical records, operative notes, and histopathological reports were collected and analysed. Results: Three patients (4.2%) had the presence of microscopic thyroid gland invasion. There were no significant associations between microscopic thyroid gland invasion and tumour subsites, histological types of a tumour nor T staging (p > 0.05) Conclusion: The incidence of microscopic thyroid gland invasion in advance carcinoma of the larynx is low, disavowing routine thyroidectomy. Limitations: Some factors such as cartilage invasion on CT imaging and central lymph node treatment were not considered due to limitations in case documentation.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalInternational Medical Journal Malaysia
Volume18
Issue number1
Publication statusPublished - 1 Mar 2019

Fingerprint

Laryngectomy
Larynx
Thyroidectomy
Thyroid Gland
Carcinoma
Incidence
Hypocalcemia
Malaysia
Hypothyroidism
Documentation
Cartilage
Medical Records
Observational Studies
Neoplasms
Retrospective Studies
Lymph Nodes
Radiation
Therapeutics

Keywords

  • Cancer of the Larynx
  • Laryngectomy
  • Thyroidectomy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

The incidence of thyroid gland invasion in patients with carcinoma of the larynx who underwent total laryngectomy. / Mawaddah, Azman; See-Sze, S.; Mat Baki, Marina; Pua, K. C.; Mohamed, Abdullah Sani.

In: International Medical Journal Malaysia, Vol. 18, No. 1, 01.03.2019, p. 13-20.

Research output: Contribution to journalArticle

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