The

In vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells

Nursyamirah Abd Razak, M. Nadeem Akhtar, Nadiah Abu, Wan Yong Ho, Sheau Wei Tan, Seema Zareen, Saiful Nizam Bin Taj-Ud-Din, Kamariah Long, Noorjahan Banu Alitheen, Swee Keong Yeap

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Curcumin is one of the promising natural products extracted from the rhizomes of curcuma longa and has been extensively investigated by researchers to explore its potential as a chemopreventive and therapeutic agent against several chronic diseases. To further enhance the cytotoxic potential of curcumin, its derivative (2E,6E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) has been synthesized and investigated, and its antitumor effect on tested on 4T1 challenged mice. BHMC was recorded with in vitro cytotoxicity on murine 4T1 breast cancer cells with IC50 value 13.66 μM, which was 2 times lower than curcumin after 72 hours of treatment. An in vivo study indicated that BHMC possessed antitumor effect on the 4T1 cells of the challenged mice by induction of apoptosis, antiproliferation, anti-inflammation and antimetastasis. This effect is better compared to curcumin treatment at the same evaluated concentration. Thus, BHMC is a potential antitumor agent against breast cancer.

Original languageEnglish
Pages (from-to)36185-36192
Number of pages8
JournalRSC Advances
Volume7
Issue number57
DOIs
Publication statusPublished - 1 Jan 2017

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Curcumin
Tumors
Cells
Derivatives
Cell death
Cytotoxicity
Biological Products
Antineoplastic Agents
Apoptosis
2,6-bis-4-(hydroxy-3-methoxybenzylidene)cyclohexanone
cyclohexanone

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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The : In vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells. / Razak, Nursyamirah Abd; Akhtar, M. Nadeem; Abu, Nadiah; Ho, Wan Yong; Tan, Sheau Wei; Zareen, Seema; Taj-Ud-Din, Saiful Nizam Bin; Long, Kamariah; Alitheen, Noorjahan Banu; Yeap, Swee Keong.

In: RSC Advances, Vol. 7, No. 57, 01.01.2017, p. 36185-36192.

Research output: Contribution to journalArticle

Razak, NA, Akhtar, MN, Abu, N, Ho, WY, Tan, SW, Zareen, S, Taj-Ud-Din, SNB, Long, K, Alitheen, NB & Yeap, SK 2017, 'The: In vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells', RSC Advances, vol. 7, no. 57, pp. 36185-36192. https://doi.org/10.1039/c7ra06580a
Razak, Nursyamirah Abd ; Akhtar, M. Nadeem ; Abu, Nadiah ; Ho, Wan Yong ; Tan, Sheau Wei ; Zareen, Seema ; Taj-Ud-Din, Saiful Nizam Bin ; Long, Kamariah ; Alitheen, Noorjahan Banu ; Yeap, Swee Keong. / The : In vivo anti-tumor effect of curcumin derivative (2 E,6 E)-2,6-bis(4-hydroxy-3-methoxybenzylidene)cyclohexanone (BHMC) on 4T1 breast cancer cells. In: RSC Advances. 2017 ; Vol. 7, No. 57. pp. 36185-36192.
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