The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity

Norlida Mat Daud @ Daud, Nurhafzan A. Ismail, Elizabeth L. Thomas, Julie A. Fitzpatrick, Jimmy D. Bell, Jonathan R. Swann, Adele Costabile, Caroline E. Childs, Camilla Pedersen, Anthony P. Goldstone, Gary S. Frost

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objective To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers. Methods In a parallel, single-blind and placebo-controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day-1 oligofructose or cellulose for 6 weeks following a 2-week run-in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post-supplementation. Results Oligofructose increased breath hydrogen (P<0.0001), late acetate concentrations (P=0.024), tended to increase total area under the curve (tAUC)420mins peptide YY (PYY) (P=0.056) and reduced tAUC 450mins hunger (P=0.034) and motivation to eat (P=0.013) when compared with cellulose. However, there was no significant difference between the groups in other parameters although within group analyses showed an increase in glucagon-like peptide 1 (GLP-1) (P=0.006) in the cellulose group and a decrease in EI during ad libitum meal in both groups. Conclusions Oligofructose increased plasma PYY concentrations and suppressed appetite, while cellulose increased GLP-1 concentrations. EI decreased in both groups. However, these positive effects did not translate into changes in BW or adiposity.

Original languageEnglish
Pages (from-to)1430-1438
Number of pages9
JournalObesity
Volume22
Issue number6
DOIs
Publication statusPublished - 2014

Fingerprint

Appetite Regulation
Adiposity
Energy Intake
Cellulose
Appetite
Hormones
Peptide YY
Glucagon-Like Peptide 1
Area Under Curve
Volunteers
Hydrogen
Body Weight
Body Weight Changes
Hunger
Volatile Fatty Acids
Meals
Motivation
Acetates
Placebos
Insulin

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Medicine(all)

Cite this

Mat Daud @ Daud, N., Ismail, N. A., Thomas, E. L., Fitzpatrick, J. A., Bell, J. D., Swann, J. R., ... Frost, G. S. (2014). The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. Obesity, 22(6), 1430-1438. https://doi.org/10.1002/oby.20754

The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. / Mat Daud @ Daud, Norlida; Ismail, Nurhafzan A.; Thomas, Elizabeth L.; Fitzpatrick, Julie A.; Bell, Jimmy D.; Swann, Jonathan R.; Costabile, Adele; Childs, Caroline E.; Pedersen, Camilla; Goldstone, Anthony P.; Frost, Gary S.

In: Obesity, Vol. 22, No. 6, 2014, p. 1430-1438.

Research output: Contribution to journalArticle

Mat Daud @ Daud, N, Ismail, NA, Thomas, EL, Fitzpatrick, JA, Bell, JD, Swann, JR, Costabile, A, Childs, CE, Pedersen, C, Goldstone, AP & Frost, GS 2014, 'The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity', Obesity, vol. 22, no. 6, pp. 1430-1438. https://doi.org/10.1002/oby.20754
Mat Daud @ Daud, Norlida ; Ismail, Nurhafzan A. ; Thomas, Elizabeth L. ; Fitzpatrick, Julie A. ; Bell, Jimmy D. ; Swann, Jonathan R. ; Costabile, Adele ; Childs, Caroline E. ; Pedersen, Camilla ; Goldstone, Anthony P. ; Frost, Gary S. / The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity. In: Obesity. 2014 ; Vol. 22, No. 6. pp. 1430-1438.
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AU - Bell, Jimmy D.

AU - Swann, Jonathan R.

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N2 - Objective To investigate the effect of nutrient stimulation of gut hormones by oligofructose supplementation on appetite, energy intake (EI), body weight (BW) and adiposity in overweight and obese volunteers. Methods In a parallel, single-blind and placebo-controlled study, 22 healthy overweight and obese volunteers were randomly allocated to receive 30 g day-1 oligofructose or cellulose for 6 weeks following a 2-week run-in. Subjective appetite and side effect scores, breath hydrogen, serum short chain fatty acids (SCFAs), plasma gut hormones, glucose and insulin concentrations, EI, BW and adiposity were quantified at baseline and post-supplementation. Results Oligofructose increased breath hydrogen (P<0.0001), late acetate concentrations (P=0.024), tended to increase total area under the curve (tAUC)420mins peptide YY (PYY) (P=0.056) and reduced tAUC 450mins hunger (P=0.034) and motivation to eat (P=0.013) when compared with cellulose. However, there was no significant difference between the groups in other parameters although within group analyses showed an increase in glucagon-like peptide 1 (GLP-1) (P=0.006) in the cellulose group and a decrease in EI during ad libitum meal in both groups. Conclusions Oligofructose increased plasma PYY concentrations and suppressed appetite, while cellulose increased GLP-1 concentrations. EI decreased in both groups. However, these positive effects did not translate into changes in BW or adiposity.

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