The flavokawains: Uprising medicinal chalcones

Nadiah Abu, Wan Y. Ho, Swee K. Yeap, M. N. Akhtar, Mohd P. Abdullah, Abdul R. Omar, Noorjahan B. Alitheen

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Plant-based compounds have been in the spotlight in search of new and promising drugs. Flavokawain A, B and C are naturally occurring chalcones that have been isolated from several medicinal plants; namely the piper methysticum or commercially known as the kava-kava. Multiple researches have been done to evaluate the bioactivities of these compounds. It has been shown that all three flavokawains may hold promising anti-cancer effects. It has also been revealed that both flavokawain A and B are involved in the induction of cell cycle arrest in several cancer cell lines. Nevertheless, flavokawain B was shown to be more effective in treating in vitro cancer cell lines as compared to flavokawain A and C. Flavokawain B also exerts antinociceptive effects as well as anti-inflammation properties. This mini-review attempts to discuss the biological properties of all the flavokawains that have been reported.

Original languageEnglish
Article number102
JournalCancer Cell International
Volume13
Issue number1
DOIs
Publication statusPublished - 22 Oct 2013
Externally publishedYes

Fingerprint

Chalcones
Kava
Cell Line
Neoplasms
Medicinal Plants
Cell Cycle Checkpoints
Inflammation
flavokawain B
Research
Pharmaceutical Preparations
flavokawain A
flavokawain C

Keywords

  • Anti-cancer
  • Anti-inflammation
  • Apoptosis
  • Flavokawain
  • Kava-kava

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

Cite this

Abu, N., Ho, W. Y., Yeap, S. K., Akhtar, M. N., Abdullah, M. P., Omar, A. R., & Alitheen, N. B. (2013). The flavokawains: Uprising medicinal chalcones. Cancer Cell International, 13(1), [102]. https://doi.org/10.1186/1475-2867-13-102

The flavokawains : Uprising medicinal chalcones. / Abu, Nadiah; Ho, Wan Y.; Yeap, Swee K.; Akhtar, M. N.; Abdullah, Mohd P.; Omar, Abdul R.; Alitheen, Noorjahan B.

In: Cancer Cell International, Vol. 13, No. 1, 102, 22.10.2013.

Research output: Contribution to journalReview article

Abu, N, Ho, WY, Yeap, SK, Akhtar, MN, Abdullah, MP, Omar, AR & Alitheen, NB 2013, 'The flavokawains: Uprising medicinal chalcones', Cancer Cell International, vol. 13, no. 1, 102. https://doi.org/10.1186/1475-2867-13-102
Abu N, Ho WY, Yeap SK, Akhtar MN, Abdullah MP, Omar AR et al. The flavokawains: Uprising medicinal chalcones. Cancer Cell International. 2013 Oct 22;13(1). 102. https://doi.org/10.1186/1475-2867-13-102
Abu, Nadiah ; Ho, Wan Y. ; Yeap, Swee K. ; Akhtar, M. N. ; Abdullah, Mohd P. ; Omar, Abdul R. ; Alitheen, Noorjahan B. / The flavokawains : Uprising medicinal chalcones. In: Cancer Cell International. 2013 ; Vol. 13, No. 1.
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