The first Malay database toward the ethnic-specific target molecular variation

Malaysian Node of the Human Variome Project

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9<sup>th</sup> October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb). Findings: Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP (http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register). Conclusions: This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.

Original languageEnglish
Article number176
JournalBMC Research Notes
Volume8
Issue number1
DOIs
Publication statusPublished - 30 Apr 2015

Fingerprint

Databases
Inborn Genetic Diseases
Research Personnel
Mutation
Polymorphism
Population Genetics
Nucleotides
Genomics
Ethnic Groups
Health
Students
Population
Single Nucleotide Polymorphism

Keywords

  • CNVs
  • Disease genes and their products
  • Ethnic-specific molecular variation database
  • Malaysian Node of the Human Variome Project
  • SNPs

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

The first Malay database toward the ethnic-specific target molecular variation. / Malaysian Node of the Human Variome Project.

In: BMC Research Notes, Vol. 8, No. 1, 176, 30.04.2015.

Research output: Contribution to journalArticle

Malaysian Node of the Human Variome Project. / The first Malay database toward the ethnic-specific target molecular variation. In: BMC Research Notes. 2015 ; Vol. 8, No. 1.
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abstract = "Background: The Malaysian Node of the Human Variome Project (MyHVP) is one of the eighteen official Human Variome Project (HVP) country-specific nodes. Since its inception in 9th October 2010, MyHVP has attracted the significant number of Malaysian clinicians and researchers to participate and contribute their data to this project. MyHVP also act as the center of coordination for genotypic and phenotypic variation studies of the Malaysian population. A specialized database was developed to store and manage the data based on genetic variations which also associated with health and disease of Malaysian ethnic groups. This ethnic-specific database is called the Malaysian Node of the Human Variome Project database (MyHVPDb). Findings: Currently, MyHVPDb provides only information about the genetic variations and mutations found in the Malays. In the near future, it will expand for the other Malaysian ethnics as well. The data sets are specified based on diseases or genetic mutation types which have three main subcategories: Single Nucleotide Polymorphism (SNP), Copy Number Variation (CNV) followed by the mutations which code for the common diseases among Malaysians. MyHVPDb has been open to the local researchers, academicians and students through the registration at the portal of MyHVP (http://hvpmalaysia.kk.usm.my/mhgvc/index.php?id=register). Conclusions: This database would be useful for clinicians and researchers who are interested in doing a study on genomics population and genetic diseases in order to obtain up-to-date and accurate information regarding the population-specific variations and also useful for those in countries with similar ethnic background.",
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AU - Merican, Amir Feisal

AU - Baig, Atif Amin

AU - Annuar, Azlina Ahmad

AU - Ismail, Endom

AU - Salahshourifar, Iman

AU - Liza-Sharmini, Ahmad Tajudin

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AU - Shah, Mohamed Irwan

AU - Johan, Muhammad Farid

AU - Hassan, Nik Norliza Nik

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AU - Yusoff, Shafini Mohamed

AU - Yusoff, Surini

AU - Tan, Soon Guan

AU - Thong, Meow Keong

AU - Wan-Isa, Hatin

AU - Abdullah, Wan Zaidah

AU - Mohamed, Zahurin

AU - Abdul Latiff, Zarina

AU - Zilfalil, Bin Alwi

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