The establishment of metabolic syndrome model by induction of fructose drinking water in male Wistar rats

Norshalizah Mamikutty, Zar Chi Thent, Shaiful Ridzwan Sapri, Natasya Nadia Sahruddin, Mohd Rafizul Mohd Yusof, Farihah Suhaimi

Research output: Contribution to journalArticle

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Abstract

Background. Metabolic syndrome can be caused by modification of diet by means of consumption of high carbohydrate and high fat diet such as fructose. Aims. To develop a metabolic syndrome rat model by induction of fructose drinking water (FDW) in male Wistar rats. Methods. Eighteen male Wistar rats were fed with FDW 20% and FDW 25% for a duration of eight weeks. The physiological changes with regard to food and fluid intake, as well as calorie intake, were measured. The metabolic changes such as obesity, dyslipidaemia, hypertension, and hyperglycaemia were determined. Data was presented in mean ± SEM subjected to one-way ANOVA. Results. Male Wistar rats fed with FDW 20% for eight weeks developed significant higher obesity parameters compared to those fed with FDW 25%. There was hypertrophy of adipocytes in F20 and F25. There were also systolic hypertension, hypertriglyceridemia, and hyperglycemia in both groups. Conclusion. We conclude that the metabolic syndrome rat model is best established with the induction of FDW 20% for eight weeks. This was evident in the form of higher obesity parameter which caused the development of the metabolic syndrome.

Original languageEnglish
Article number263897
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Fructose
Drinking Water
Wistar Rats
Rats
Obesity
Nutrition
Hyperglycemia
Hypertension
Diet Therapy
Hypertriglyceridemia
High Fat Diet
Dyslipidemias
Analysis of variance (ANOVA)
Adipocytes
Hypertrophy
Analysis of Variance
Eating
Fats
Carbohydrates
Scanning electron microscopy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Mamikutty, N., Thent, Z. C., Sapri, S. R., Sahruddin, N. N., Mohd Yusof, M. R., & Suhaimi, F. (2014). The establishment of metabolic syndrome model by induction of fructose drinking water in male Wistar rats. BioMed Research International, 2014, [263897]. https://doi.org/10.1155/2014/263897

The establishment of metabolic syndrome model by induction of fructose drinking water in male Wistar rats. / Mamikutty, Norshalizah; Thent, Zar Chi; Sapri, Shaiful Ridzwan; Sahruddin, Natasya Nadia; Mohd Yusof, Mohd Rafizul; Suhaimi, Farihah.

In: BioMed Research International, Vol. 2014, 263897, 2014.

Research output: Contribution to journalArticle

Mamikutty, Norshalizah ; Thent, Zar Chi ; Sapri, Shaiful Ridzwan ; Sahruddin, Natasya Nadia ; Mohd Yusof, Mohd Rafizul ; Suhaimi, Farihah. / The establishment of metabolic syndrome model by induction of fructose drinking water in male Wistar rats. In: BioMed Research International. 2014 ; Vol. 2014.
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