Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus: Analisa gen osteoblastogenesis dan antioksidan

Translated title of the contribution: The effects of virgin coconut oil on postmenopausal osteoporotic bone: Analyses on osteoblastogenesis and antioxidant genes

Shidqiyyah Abdul-Hamid, Norliza Muhammad, Isa Naina Mohamed

Research output: Contribution to journalArticle

Abstract

Postmenopausal osteoporosis is one of the main health problems in aging women. It was due to several factors including oxidative stress, which can be controlled through intake of antioxidants from food sources. Virgin coconut oil (VCO) is one of the natural product rich in antioxidants and has been proven to protect osteoporotic bone. This study was conducted to gain in-depth understanding on virgin coconut oil's activity on osteoporosis at molecular level. Thirty two female Sprague-Dawley rats were divided into four groups, namely Sham operated group, ovariectomized control group (Ovx+Ctrl), ovariectomized with VCO treatment (Ovx+VCO), and ovariectomized with estrogen treatment (Ovx+E). All treatments were administered orally for ten weeks. Bone samples were obtained to examine changes on expression of superoxide dismutase (SOD), glutathione peroxidase (GPX), osteocalcin and runt-related transcription factor 2 (Runx2) genes. The results indicated that rats receiving VCO treatment had experienced significant increments in SOD, GPX and osteocalcin gene expressions compared to the ovariectomized control group, besides the gene expressions of Runx2 which also showed an increment pattern. In conclusion, VCO helps to protect bone in osteoporotic rat model by increasing the expressions of antioxidant genes and genes which increase the osteoblast acitivities.

Original languageIndonesian
Pages (from-to)1815-1822
Number of pages8
JournalSains Malaysiana
Volume45
Issue number12
Publication statusPublished - 1 Dec 2016

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Antioxidants
Bone and Bones
Genes
Osteocalcin
Glutathione Peroxidase
Gene Expression
Superoxide Dismutase
Control Groups
Postmenopausal Osteoporosis
Therapeutics
Biological Products
Osteoblasts
Osteoporosis
Sprague Dawley Rats
coconut oil
Estrogens
Oxidative Stress
Transcription Factors
Eating
Health

Keywords

  • Osteoporosis
  • Ovariectomized rat model
  • Postmenopausal
  • Virgin coconut oil

ASJC Scopus subject areas

  • General

Cite this

Tindakan minyak kelapa dara terhadap tulang osteoporosis pascamenopaus : Analisa gen osteoblastogenesis dan antioksidan. / Abdul-Hamid, Shidqiyyah; Muhammad, Norliza; Naina Mohamed, Isa.

In: Sains Malaysiana, Vol. 45, No. 12, 01.12.2016, p. 1815-1822.

Research output: Contribution to journalArticle

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