The effects of propranolol and tocotrienol on skeletal muscle contraction and lipid peroxidation products in hyperthyroid rats

Zaiton Zakaria, Z. Merican, B. A K Khalid, Jamaludin Mohamed

Research output: Contribution to journalArticle

Abstract

Prolonged thyroxine treatment of rats significantly depressed contractile properties and increased conjugated diene (CD) and malonaldehyde (MDA)levels of rat soleus muscles. Concomitant propranolol administration with thyroxine to rats (HP rats) for 3 weeks did not improve the reduction in soleus muscle contractility but caused the muscle to fatigue less readily than the hyperthyroid rats. MDA and CD levels of HP rats were not significantly different from those of hyperthyroid rats. Concomitant tocotrienol administration with thyroxine to rats (HE rats) improved some but not all of the parameters of soleus muscle function but returned MDA and CD to control level. The concomitant administration of propranolol together with tocotrienol and thyroxine improved muscle function still further but MDA and CD levels were raised midway between HP and HE rats. The study suggests that propranolol and tocotrienol given separately or in combination has a beneficial effect on soleus muscle function in hyperthyroid rats but this effect is most likely unrelated to the decrease in MDA and CD levels.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalAsia Pacific Journal of Pharmacology
Volume10
Issue number1
Publication statusPublished - 1995

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Tocotrienols
Hyperthyroidism
Muscle Contraction
Propranolol
Lipid Peroxidation
Skeletal Muscle
Thyroxine
Muscle Fatigue
Malondialdehyde

Keywords

  • hyperthyroidism
  • lipid peroxidation products
  • muscle contraction
  • propranolol
  • tocotrienol

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effects of propranolol and tocotrienol on skeletal muscle contraction and lipid peroxidation products in hyperthyroid rats. / Zakaria, Zaiton; Merican, Z.; Khalid, B. A K; Mohamed, Jamaludin.

In: Asia Pacific Journal of Pharmacology, Vol. 10, No. 1, 1995, p. 9-16.

Research output: Contribution to journalArticle

Zakaria, Zaiton ; Merican, Z. ; Khalid, B. A K ; Mohamed, Jamaludin. / The effects of propranolol and tocotrienol on skeletal muscle contraction and lipid peroxidation products in hyperthyroid rats. In: Asia Pacific Journal of Pharmacology. 1995 ; Vol. 10, No. 1. pp. 9-16.
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