The effects of palm tocotrienol on metabolic syndrome and bone loss in male rats induced by high-carbohydrate high-fat diet

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Abstract

Inflammation is a possible mediator of the relationship between metabolic syndrome (MetS) and osteoporosis. Palm tocotrienol, an anti-inflammatory agent, has been reported to exert beneficial effects for the treatment of MetS and osteoporosis individually. This study aimed to investigate the potential role of palm tocotrienol in preventing both MetS and bone loss in male rats via alleviating the inflammatory response. In this study, MetS was established in the rats fed with HCHF diet. This was accompanied by bone loss and elevated pro-inflammatory cytokine levels. Supplementation of palm tocotrienol improved MetS parameters, trabecular bone microstructure, bone strength, and reduced pro-inflammatory cytokines in the HCHF rats. A dose-dependent effect of palm tocotrienol was also observed in preventing MetS conditions. In conclusion, palm tocotrienol prevents both MetS and bone loss, possibly through its anti-inflammatory properties.

Original languageEnglish
Pages (from-to)246-254
Number of pages9
JournalJournal of Functional Foods
Volume44
DOIs
Publication statusPublished - 1 May 2018

Fingerprint

Tocotrienols
high carbohydrate diet
tocotrienols
metabolic syndrome
High Fat Diet
high fat diet
Carbohydrates
bones
Bone and Bones
rats
osteoporosis
Osteoporosis
cytokines
Anti-Inflammatory Agents
inflammation
Cytokines
anti-inflammatory agents
bone strength
anti-inflammatory activity
microstructure

Keywords

  • Cholesterol
  • Glucose
  • Obesity
  • Osteoporosis
  • Triglycerides
  • Vitamin E

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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title = "The effects of palm tocotrienol on metabolic syndrome and bone loss in male rats induced by high-carbohydrate high-fat diet",
abstract = "Inflammation is a possible mediator of the relationship between metabolic syndrome (MetS) and osteoporosis. Palm tocotrienol, an anti-inflammatory agent, has been reported to exert beneficial effects for the treatment of MetS and osteoporosis individually. This study aimed to investigate the potential role of palm tocotrienol in preventing both MetS and bone loss in male rats via alleviating the inflammatory response. In this study, MetS was established in the rats fed with HCHF diet. This was accompanied by bone loss and elevated pro-inflammatory cytokine levels. Supplementation of palm tocotrienol improved MetS parameters, trabecular bone microstructure, bone strength, and reduced pro-inflammatory cytokines in the HCHF rats. A dose-dependent effect of palm tocotrienol was also observed in preventing MetS conditions. In conclusion, palm tocotrienol prevents both MetS and bone loss, possibly through its anti-inflammatory properties.",
keywords = "Cholesterol, Glucose, Obesity, Osteoporosis, Triglycerides, Vitamin E",
author = "Wong, {Sok Kuan} and {Kok Yong}, Chin and Farihah Suhaimi and Fairus Ahmad and Soelaiman, {Ima Nirwana}",
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T1 - The effects of palm tocotrienol on metabolic syndrome and bone loss in male rats induced by high-carbohydrate high-fat diet

AU - Wong, Sok Kuan

AU - Kok Yong, Chin

AU - Suhaimi, Farihah

AU - Ahmad, Fairus

AU - Soelaiman, Ima Nirwana

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Inflammation is a possible mediator of the relationship between metabolic syndrome (MetS) and osteoporosis. Palm tocotrienol, an anti-inflammatory agent, has been reported to exert beneficial effects for the treatment of MetS and osteoporosis individually. This study aimed to investigate the potential role of palm tocotrienol in preventing both MetS and bone loss in male rats via alleviating the inflammatory response. In this study, MetS was established in the rats fed with HCHF diet. This was accompanied by bone loss and elevated pro-inflammatory cytokine levels. Supplementation of palm tocotrienol improved MetS parameters, trabecular bone microstructure, bone strength, and reduced pro-inflammatory cytokines in the HCHF rats. A dose-dependent effect of palm tocotrienol was also observed in preventing MetS conditions. In conclusion, palm tocotrienol prevents both MetS and bone loss, possibly through its anti-inflammatory properties.

AB - Inflammation is a possible mediator of the relationship between metabolic syndrome (MetS) and osteoporosis. Palm tocotrienol, an anti-inflammatory agent, has been reported to exert beneficial effects for the treatment of MetS and osteoporosis individually. This study aimed to investigate the potential role of palm tocotrienol in preventing both MetS and bone loss in male rats via alleviating the inflammatory response. In this study, MetS was established in the rats fed with HCHF diet. This was accompanied by bone loss and elevated pro-inflammatory cytokine levels. Supplementation of palm tocotrienol improved MetS parameters, trabecular bone microstructure, bone strength, and reduced pro-inflammatory cytokines in the HCHF rats. A dose-dependent effect of palm tocotrienol was also observed in preventing MetS conditions. In conclusion, palm tocotrienol prevents both MetS and bone loss, possibly through its anti-inflammatory properties.

KW - Cholesterol

KW - Glucose

KW - Obesity

KW - Osteoporosis

KW - Triglycerides

KW - Vitamin E

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