The effects of hydroxychloroquine on endothelial dysfunction

Rahana Abd Rahman, Padma Murthi, Harmeet Singh, Seshini Gurusinghe, Joanne C. Mockler, Rebecca Lim, Euan M. Wallace

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-α and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-α and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-α induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.

Original languageEnglish
Pages (from-to)259-262
Number of pages4
JournalPregnancy Hypertension
Volume6
Issue number4
DOIs
Publication statusPublished - 1 Oct 2016

Fingerprint

Hydroxychloroquine
Antimalarials
Endothelin-1
Pre-Eclampsia
Serum
Systemic Lupus Erythematosus
Autoimmune Diseases
Anti-Inflammatory Agents
Pharmaceutical Preparations

Keywords

  • Endothelial dysfunction
  • Endothelin-1
  • Hydroxychloroquine
  • Preeclampsia
  • Preeclamptic serum
  • TNF-α

ASJC Scopus subject areas

  • Internal Medicine
  • Obstetrics and Gynaecology

Cite this

Abd Rahman, R., Murthi, P., Singh, H., Gurusinghe, S., Mockler, J. C., Lim, R., & Wallace, E. M. (2016). The effects of hydroxychloroquine on endothelial dysfunction. Pregnancy Hypertension, 6(4), 259-262. https://doi.org/10.1016/j.preghy.2016.09.001

The effects of hydroxychloroquine on endothelial dysfunction. / Abd Rahman, Rahana; Murthi, Padma; Singh, Harmeet; Gurusinghe, Seshini; Mockler, Joanne C.; Lim, Rebecca; Wallace, Euan M.

In: Pregnancy Hypertension, Vol. 6, No. 4, 01.10.2016, p. 259-262.

Research output: Contribution to journalArticle

Abd Rahman, R, Murthi, P, Singh, H, Gurusinghe, S, Mockler, JC, Lim, R & Wallace, EM 2016, 'The effects of hydroxychloroquine on endothelial dysfunction', Pregnancy Hypertension, vol. 6, no. 4, pp. 259-262. https://doi.org/10.1016/j.preghy.2016.09.001
Abd Rahman, Rahana ; Murthi, Padma ; Singh, Harmeet ; Gurusinghe, Seshini ; Mockler, Joanne C. ; Lim, Rebecca ; Wallace, Euan M. / The effects of hydroxychloroquine on endothelial dysfunction. In: Pregnancy Hypertension. 2016 ; Vol. 6, No. 4. pp. 259-262.
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