Abstract
Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-α and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-α and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-α induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.
| Original language | English |
|---|---|
| Pages (from-to) | 259-262 |
| Number of pages | 4 |
| Journal | Pregnancy Hypertension |
| Volume | 6 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1 Oct 2016 |
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Keywords
- Endothelial dysfunction
- Endothelin-1
- Hydroxychloroquine
- Preeclampsia
- Preeclamptic serum
- TNF-α
ASJC Scopus subject areas
- Internal Medicine
- Obstetrics and Gynaecology
Cite this
The effects of hydroxychloroquine on endothelial dysfunction. / Abd Rahman, Rahana; Murthi, Padma; Singh, Harmeet; Gurusinghe, Seshini; Mockler, Joanne C.; Lim, Rebecca; Wallace, Euan M.
In: Pregnancy Hypertension, Vol. 6, No. 4, 01.10.2016, p. 259-262.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effects of hydroxychloroquine on endothelial dysfunction
AU - Abd Rahman, Rahana
AU - Murthi, Padma
AU - Singh, Harmeet
AU - Gurusinghe, Seshini
AU - Mockler, Joanne C.
AU - Lim, Rebecca
AU - Wallace, Euan M.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-α and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-α and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-α induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.
AB - Hydroxychloroquine is an anti-malarial drug which, due to its anti-inflammatory and immunomodulatory effects, is widely used for the treatment of autoimmune diseases. In a model of systemic lupus erythematosus hydroxychloroquine has been shown to exert protective endothelial effects. In this study, we aimed to investigate whether hydroxychloroquine was endothelial protective in an in vitro model of TNF-α and preeclamptic serum induced dysfunction. We showed that hydroxychloroquine significantly reduced the production of TNF-α and preeclamptic serum induced endothelin-1 (ET-1). Hydroxychloroquine also significantly mitigated TNF-α induced impairment of angiogenesis. These findings support the further assessment of hydroxychloroquine as an adjuvant therapy in preeclampsia.
KW - Endothelial dysfunction
KW - Endothelin-1
KW - Hydroxychloroquine
KW - Preeclampsia
KW - Preeclamptic serum
KW - TNF-α
UR - http://www.scopus.com/inward/record.url?scp=85006272235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006272235&partnerID=8YFLogxK
U2 - 10.1016/j.preghy.2016.09.001
DO - 10.1016/j.preghy.2016.09.001
M3 - Article
C2 - 27939463
AN - SCOPUS:85006272235
VL - 6
SP - 259
EP - 262
JO - Pregnancy Hypertension
JF - Pregnancy Hypertension
SN - 2210-7789
IS - 4
ER -