The effects of cosmos caudatus (Ulam Raja) supplementation on serum and bone minerals levels in ovariectomized rats

Norazlina Mohamed, Mohamed Zahir Anverdeen, Nurul Ain Rahim, Chia Jia Wen, Choo Wan Hee, Nurul Hafizah Abas, Muhamad Arizi Aziz

Research output: Contribution to journalArticle

Abstract

Summary. Osteoporosis is a consequence of estrogen deficiency and has been associated with oxidative stress. Cosmos caudatus (ulam raja), a local plant, has been shown to improve bone histomorphometry in ovariectomized rats. This study further determined the effects of Cosmos caudatus on serum and bone minerals levels in ovariectomised rats. Female Sprague Dawley rats were divided into 4 groups, (I) sham operated (SO) (II) ovariectomised (OVX) (III) ovariectomised + 500mg/kg Cosmos caudatus extract (CC) and (IV) ovariectomised + estrogen 64.5 ug/kg of rat weight (E2). Rats were treated for 8 weeks. Ovariectomy reduced serum calcium and phosphate levels compared to SO group (p = 0.042 for both) but did not cause any changes in bone minerals levels. Groups treated with CC and E2 showed significant increase in serum calcium levels (p= 0.018 for both) and serum phosphate levels (p= 0.016, p= 0.002 respectively) compared to ovariectomized group. However, both Cosmos caudatus and E2 did not affect the minerals levels of femur and fifth lumbar bones (L5). In conclusion, Cosmos caudatus is comparable to estrogen in improving estrogen deficient-induced osteoporosis by maintaining serum minerals homeostasis. Industrial relevance. Osteoporosis has grown to be a major concern especially among postmenopausal women. Studies have been done extensively in finding alternative treatment for osteoporosis. This is in view of the various side effects caused by the existing treatment agents such as estrogen. Cosmos caudatus, one of the local plants, has been explored and was observed to improve bone histomorphometric in ovariectomised rats. It has also been shown to enhance fracture healing in ovariectomized rats. This study further examined the effects of Cosmos caudatus on minerals homeostasis which further proved the effectiveness of this plant as an alternative treatment for osteoporosis.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalInternational Journal of Applied Research in Natural Products
Volume9
Issue number4
Publication statusPublished - 2016

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Skates (Fish)
Minerals
Osteoporosis
Estrogens
Bone and Bones
Serum
Homeostasis
Fracture Healing
Ovariectomy
Femur
Sprague Dawley Rats
Oxidative Stress
Therapeutics
Phosphates
Calcium
Weights and Measures

Keywords

  • Bone minerals
  • Cosmos caudatus
  • Estrogen
  • Ovariectomy
  • Serum minerals

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Complementary and alternative medicine

Cite this

The effects of cosmos caudatus (Ulam Raja) supplementation on serum and bone minerals levels in ovariectomized rats. / Mohamed, Norazlina; Anverdeen, Mohamed Zahir; Rahim, Nurul Ain; Wen, Chia Jia; Hee, Choo Wan; Abas, Nurul Hafizah; Aziz, Muhamad Arizi.

In: International Journal of Applied Research in Natural Products, Vol. 9, No. 4, 2016, p. 1-7.

Research output: Contribution to journalArticle

Mohamed, Norazlina ; Anverdeen, Mohamed Zahir ; Rahim, Nurul Ain ; Wen, Chia Jia ; Hee, Choo Wan ; Abas, Nurul Hafizah ; Aziz, Muhamad Arizi. / The effects of cosmos caudatus (Ulam Raja) supplementation on serum and bone minerals levels in ovariectomized rats. In: International Journal of Applied Research in Natural Products. 2016 ; Vol. 9, No. 4. pp. 1-7.
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