The effects of consumption of edible oils for a period of four months on the ultrastructure of rat aorta

Faizah Othman, Z. Merican, M. F. Hassan, B. A K Khalid, Jamaludin Mohamed, M. Radzi

Research output: Contribution to journalArticle

Abstract

Edible oils show different effects on lipid profile and propensity for producing lipid peroxidation products. These two properties of edible oils can affect arterial structure ultimately leading to atherosclerosis. This paper investigates the effects of feeding edible oils for a period of four months to normotensive rats on the ultrastructure of the aorta of normotensive rats. The study shows that ghee caused a marked intimal thickening of the aorta with apparent increase of the connective tissue elements. There are changes in the endothelial cells such as increased frequency occurrence of cytoplasmic processes and vacuoles, besides occasional macrophages and smooth muscle cells in the intima of ghee-fed group of rats as compared to the palm oil or soya bean oil. This study suggests that ingestion of ghee is more likely to lead to atherosclerosis than ingestion of palm oil or soya bean oil.

Original languageEnglish
Pages (from-to)115-121
Number of pages7
JournalAsia Pacific Journal of Pharmacology
Volume13
Issue number4
Publication statusPublished - 1998

Fingerprint

Aorta
Oils
Soybean Oil
Atherosclerosis
Eating
Tunica Intima
Vacuoles
Connective Tissue
Lipid Peroxidation
Smooth Muscle Myocytes
Endothelial Cells
Macrophages
Lipids
Ghee
palm oil

Keywords

  • Aorta
  • Ghee
  • Normotensive rats
  • Palm oil
  • Soya bean oil

ASJC Scopus subject areas

  • Pharmacology

Cite this

The effects of consumption of edible oils for a period of four months on the ultrastructure of rat aorta. / Othman, Faizah; Merican, Z.; Hassan, M. F.; Khalid, B. A K; Mohamed, Jamaludin; Radzi, M.

In: Asia Pacific Journal of Pharmacology, Vol. 13, No. 4, 1998, p. 115-121.

Research output: Contribution to journalArticle

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